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LSUHSC research identifies co-factors critical to PTSD development

Research led by Ya-Ping Tang, MD, PhD, Associate Professor of Cell Biology and Anatomy at LSU Health Sciences Center New Orleans, has found that the action of a specific gene occurring during exposure to adolescent trauma is critical for the development of adult-onset Post-Traumatic Stress Disorder (PTSD.) The findings are published in PNAS Online Early Edition the week of April 1-5, 2013.

"This is the first study to show that a timely manipulation of a certain neurotransmitter system in the brain during the stage of trauma exposure is potentially an effective strategy to prevent the pathogenesis of PTSD," notes Dr. Tang.

The research team conducted a series of experiments using a specific strain of transgenic mice, in which the function of the gene can be suppressed, and then restored. The model combined exposure to adolescent trauma as well as an acute stressor. Clinically PTSD may occur immediately following a trauma, but in many cases, a time interval may exist between the trauma and the onset of disease. Exposure to a second stress or re-victimization can be an important causative factor. However, the researchers discovered that exposure to both adolescent trauma and to acute stress was not enough to produce consistent PTSD-like behavior. When exposure to trauma and stress was combined with the function of a specific transgene called CCKR-2, consistent PTSD-like behavior was observed in all of the behavioral tests, indicating that the development of PTSD does not depend only on the trauma itself.

As a predominant form of human anxiety disorders, PTSD affects 7.8% of people between 15-54 years in the United States. PTSD can cause feelings of hopelessness, despair and shame, employment and relationship problems, anger, and sleep difficulties. Additionally, PTSD can increase the risk of other mental health conditions including depression, substance abuse, eating disorders, and suicidal thoughts, as well as certain medical conditions including cardiovascular disease, chronic pain, autoimmune disorders, and musculoskeletal conditions.

A favored current theory of the development of anxiety disorders, including PTSD, is a gene/environment interaction. This study demonstrated that the function of the CCKR-2 gene in the brain is a cofactor, along with trauma insult, and identified a critical time window for the interaction in the development of PTSD.

"Once validated in human subjects, our findings may help target potential therapies to prevent or cure this devastating mental disorder," Dr. Tang concludes.

Other members of the LSUHSC research team included Anu Joseph, Takayoshi Mamiya, Ling-Ling Yang, and Na Yu, and scientists from Luzhou Medical College and the University of Chicago also participated. The research was supported by grants from the National Institutes of Health, the Alzheimer's Association, and the LSU Health Sciences Center New Orleans School of Medicine.

LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC New Orleans consists of a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, Schools of Allied Health Professions and Graduate Studies, and the only School of Nursing within an academic health center in the State of Louisiana.

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How exactly to End Diabetes From Starting - U.S. World & news Report (blog)

Tamara Duker Freuman The Centers for Disease Control and Prevention (CDC) released a stunning figure a couple weeks ago: Eighty-nine per cent of the 79 million Americans with pre-diabetes aren't even aware they've the condition. Put simply, there are 70.3 million Americans on the age of 20 at high risk for developing diabetes at any time a and it wasn't even known by them. This is troubling for several reasons. For entrepreneurs, diabetes is a chronic problem associated with a low life expectancy; the common 50 year old with diabetes loses approximately 8 1/2 years of endurance. Avoidance, therefore, results in increased likelihood of a significantly longer lifea'the end that is less likely to be spent shuttling to and from doctor's offices and hospitals. Secondly, there are several proven approaches to delaya'if perhaps not totally preventa'the onset of diabetes in individuals with prediabetes. But unless you know you are at risk, it is unlikely you'll stumble upon these preventive measures in time to halt the progression toward full-fledged diabetes. In any given year, about 11 % of men and women with prediabetes "graduate" to developing diabetes. [See Diet, Diabetes and Doubt: Is Preventive Medicine Dropped in Space?] Prediabetes is just a situation by which your ability to manage blood glucose is impaired, but not so impaired concerning be eligible for full-blown diabetes. It results from decreased sensitivity to the hormone insulin, which helps bring sugar from the blood in to cells where it can be used for energy. Importantly, pre-diabetes is reversible; glucose tolerance may improve whenever a person's metabolic situation enhances. Listed here is how: Exercise is moderated by a Very. That you don't need certainly to spend hours everyday sweating up a in a spin class to experience the diabetes-preventing effects of exercise. Heck, that you don't actually have to join a fitness center. Research shows that 2 1/2 hours each week of even relaxing real activitya'like quick walkinga'is enough to substantially improve glucose tolerance. This results in a walk five times per weeka'though needless to say, if you should be up to the task, more is better yet. Exercise works because muscles in action are able to occupy sugar from the blood without the help of insulin, so get moving! [See 7 Mind-Blowing Great things about Exercise.] A Really moderate weight reduction. Evidence shows that it only takes about a 5 to 7 percent weight loss to delay by a long period the onset of diabetes among obese individuals with prediabetes. To place that in perception, a 5-foot-4-inch person with pounds are weighed 160 by pre-diabetes who would just need to drop about 11 pounds to reduce her danger of developing diabetes. A five-foot-11-inch person weighing 220 pounds would have to drop about 15 pounds going to this target. Put simply, one doesn't need certainly to drop spectacular, "The Biggest Loser"-scale amounts of fat to simply help protect against diabetes. In a few people, small changes in lifestyle like avoiding sweetened products or decreasing carbohydrate portions may be adequate to promote this amount of fat loss. [See When Research Met The Largest Loser.] Actually, research indicates that moderate fat loss, combined with 150 minutes of weekly exercise, paid down by 58 % the risk of developing diabetes in a citizenry of obese people with prediabetes. Particularly, members who began considering on average 207 pounds dropped about 12 pounds (or 5.7 percent of their body weight). Somewhat, this result was substantially more efficient than having an insulin-sensitizing drug called metformin in avoiding the onset of diabetes. a Curcumin supplements. Recent study out of Thailand that was printed in Diabetes Care proposed that supplementing curcumina'the ingredient in the bright yellow, anti-inflammatory tart turmerica'may be protective against diabetes among people who have pre-diabetes. [See Dr. Weil's Anti inflammatory Diet.] Though it was merely a single, little study (237 people), it was smartly designed and revealed a really promising scientific benefit: Of the group randomly assigned to simply take 500 milligrams of curcumin supplements 3 x daily, none advanced to develop diabetes after eight months. By way of contrast, 16 percent of participants in the placebo group did develop diabetes in once period. Because the study population was homogeneously Asian, it is unclear whether these effects could be extrapolated to a general American population. And considering that the research was short, it is unclear perhaps the benefit could have extended after dark nine months studied. Nevertheless, provided how inexpensive and well-tolerated this natural supplement seems to be, it could be worth speaking with your physician or dietitian to see if curcumin can be an ideal supplement for you yourself to consider. With 70 million of us counted on the list of unknowing rates of people with pre-diabetes, it is statistically likely that you or someone you know belongs for this class. Risk facets for pre-diabetes include being overweight or obese; having a family history of diabetes; having your own history of gestational diabetes in pregnancy; having given birth to a baby weighing a lot more than seven pounds; and owned by one of several ethnic groups, including African American, Hispanic, Asian American, Pacific Islander or Indigenous American. If you belong to one of these brilliant classes, consider making an appointment for a check-up; prediabetes could be examined with simple blood tests from your own primary care physician. Knowing your position will make a massive big difference in before it is too late turning the tide against progression to diabetes. [See 7 Items to Know when you have Received a Diabetes Diagnosis.] Hungry for more? Create to eatandrun@usnews.com along with your questions, concerns, and feedback. Tamara Duker Freuman, MS, RD, CDN, is a NYC-based registered dietitian whose clinical practice focuses on digestive disorders, Celiac Infection, and food intolerances. Her particular weblog, www.tamaraduker.com, targets healthful eating and gluten-free living.

Diabetes Reduction type Wednesday, April 2 - Rapid City Journal

Spearfish Local Hospitalas (SPRH) diabetes teachers will show a Diabetes Prevention class Tuesday, April 2. The class happens from 9 a.m. to 11 a.m. at the SPRH FMC Conference Room at 1440 N. Main St. Charge of the type is $35 per person and features a pedometer, portion plate and cook book. Preregistration is required. Individuals may receive education about healthier food planning, exercise and approaches to minimize other diabetic risk facets. No doctor order is important to wait the school. Based on the American Diabetes Association, individuals with a higher risk for getting diabetes include: men and women 45 years or older, particularly those who are overweight; non-Caucasians; individuals who have had gestational diabetes; have had an infant weighing over 9 pounds; or have high blood pressure or high body fats. To learn more about the managing prediabetes school or to preregister, call the SPRH Diabetes Education Department at 644-4251.

Link: Study Pinpoints Women at Risk for Blood Clots From Pregnancy

[UPDATED] [AUDIO] Lilly About to Increase Diabetes Investment - Inside INdiana Business (news release)

The program calls for the center to be complete by 2016. Last year, Lilly proposed a $140 million expansion of the insulin production operations. May 2, 2013 Media Release INDIANAPOLIS, Ind. - Eli Lilly and Company (NYSE: LLY) today reported that it is working directly with the city on a proposal to take a position an additional $180 million in the business's Indianapolis-based insulin production operations. The investment is as well as the company's November 2012 statement of a $140 million expansion of the company's Indianapolis insulin manufacturing operations. Together, the assets could help the growing insulin demand to be met by Lilly given the increase in diabetes incidence throughout the U.S. Lilly is also proposing several other ancillary expense projects totaling about $80 million, including a $40 million product-inspection middle. The newest $180 million planned investment is two-fold: -Lilly might add a second insulin cartridge-filling line to the overall scope of the previously introduced expansion, taking the sum total to two insulin-cartridge-filling lines. -The next piece of the expense would support Lilly's efforts to improve its insulin-active-ingredient production capacity. Designed to increase annual insulin result, this energy could help Lilly increase output without creating a new manufacturer or increasing its cost structure. The project also would support Lilly's commitment to keep up the greatest quality standards. "Lilly is making significant investments to aid our current portfolio of diabetes medicines," said Enrique Conterno, president of Lilly Diabetes. "We may also be continuing to search for better treatments and new. We've one of many strongest diabetes pipelines inside our history--including four compounds in late-stage development--that could help support the needs of people with diabetes." "We feel Indianapolis is a good place for this investment, as we will continue steadily to enjoy the engaged, dedicated, and highly skilled work force we've in this city," said Myles O'Neill, Lilly manufacturing's senior vice president of global parenteral drug product and delivery units. "Lilly could have made this investment anywhere on earth, nevertheless the undeniable fact that it continues to develop in Indianapolis is really a testament to the truly amazing business climate and workforce inside our city," said Mayor Greg Ballard. "I want to underscore that despite tough economic times, before half a year, Lilly has reported proposed plans to get higher than a quarter of a billion dollars within our town and create jobs for a lot of highly qualified people. This really is great news for Indianapolis." Development supporting the additional insulin-cartridge-filling line could possibly be completed by 2016. During the development period, construction-trade staffing would average about 100, with maximum employment of around 140 workers at the website. Construction work in the insulin-active-ingredient production area could possibly be finished by December and working by March 2014. Lilly anticipates that construction-worker numbers would average around 70 and maximum at around 160 throughout the proposed project. This portion of the investment would help Lilly to improve its annual output of insulin effective ingredient--the medicine that switches into the vials and tubes that people use. Once working, around 175 full-time, highly skilled, specific technicians, boffins, and technicians could be had a need to handle operations in the cartridge-filling and insulin-active-ingredient production areas. Answering insulin cartridges would have been a new technology for Lilly's U.S. Production operations. Lilly websites in the U.S. currently only complete insulin vials, which are utilized with a traditional syringe or an insulin pump. Tubes, nevertheless, are used in insulin "pens," which are increasing in popularity in the U.S. About Eli Lilly and Company Lilly, a respected innovation-driven corporation, is having a growing collection of pharmaceutical products and services through the use of the latest research from a unique global laboratories and from partnerships with eminent scientific companies. Headquartered in Indianapolis, Ind., Lilly offers responses - through drugs and information - for a few of the world's most critical medical needs. Extra information about Lilly can be acquired at www.lilly.com. C-LLY Source: Eli Lilly and Co.

Via: Study Pinpoints Women at Risk for Blood Clots From Pregnancy

Cancer individuals in Canada got weak doses of chemo drugs - CNN International

(CNN) -- Near 1,200 patients in Canada got lower-than-intended doses of chemotherapy drugs, officers said Tuesday, in an incident that's sure to upset these patients and their loved ones. Additionally it raises issues about how potentially life-saving drugs are treated. Cancer Care Ontario, a government agency, reported that 990 people were afflicted at four hospitals -- London Health Sciences Centre, Windsor Regional Hospital, Lakeridge Health and Peterborough Regional Health Centre. Still another 186 patients were underdosed at Saint John Regional Hospital in New Brunswick, said hospital speaker Janet Hogan. The drugs involved were ordered by the hospitals from a dealer that labels and produces the medications, based on Cancer Care Ontario. The company didn't identify the provider. The issue, which involved cyclophosphamide and gemcitabine, was found late last month. Cyclophosphamide is typically used to treat cancer of the ovaries, breast, blood and lymph technique, while gemcitabine could be used in the treating ovarian, breast, pancreatic and lung cancers. New late-stage breast cancer therapy approved "It is important to see that chemotherapy planning and delivery is a complicated process and as a result of this difficulty, you will find quality initiatives at Cancer Care Ontario, vice president of medical programs and options for potential error," Dr. Carol Sawka, said in a record. "In Ontario, we've put in many measures to reduce these potential sources of error and we will continue to ensure that high quality care and patient safety are the focus and the energy of the system." More details were provided by sawka on the situation when she talked to CNN internet CTV. She said the situation with the drugs, which are given intravenously, was first recognized by a pharmacy technician. "Our quotes right now are that the range of underdosing was from a few months to perhaps twenty years significantly less than what it will have been," she told CTV. Sawka declined to take a position on which the consequences might be for people, worrying "it's really difficult to generalize." Their families and affected individuals are now being advised of the error this week. "We simply take these seriously. You want to learn from it. We desire to make certain it never happens again, and that's what we are doing at this time by dealing with the hospitals and the supplier," Sawka said. Sick guy of Europe: Life-support medicines run short in Greece CNN's Miriam Falco and Elwyn Lopez brought for this survey.

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