The incidence of higher level breast cancer among younger women, ages 25 to 39, may have improved slightly over the last three decades, based on research produced Tuesday. But more research is necessary to confirm the finding, that has been based on an analysis of research, the studyas experts said. They do not understand what may have caused the apparent increase. Some outside experts wondered whether the increase was true, and expressed concerns that the record could discourage women unnecessarily. The research, revealed in The Journal of the American Medical Association, found that advanced cases rose to 2.9 per 100,000 younger women in 2009, from 1.53 per 100,000 women in 1976 a' a growth of 1.37 cases per 100,000 women in 34 years. The totals were about 250 such cases per year in the mid-1970s, and over 800 per year in '09. Although tiny, the increase was statistically significant, and the researchers said it was worrisome because it involved cancer that had already spread to organs like the liver or lungs by the time it was diagnosed, which considerably decreases chances of survival. For now, the only advice the researchers will offer to young women is to view a physician quickly if they observe piles, pain or other improvements in the breast, and never to believe that they cannot have breast cancer because they are young and healthy, or have no genealogy of the illness. Updated cancer can and occurs in young women,a said Dr. Rebecca H. Brown, the initial author of the medical and study director of the adolescent and young adult oncology method at Seattle Childrenas Hospital. But Dr. Johnson noted that there's no evidence that testing helps younger women who have a typical risk for the disease and no symptoms. aWeare definitely not advocating that women get mammography at a youthful age than is usually specified,a she said. Specialist teams vary about when screening must begin; some say at age 40, others 50. Breast cancer isn't common in young women; only 1.8 percent of most cases are diagnosed in women from 10 percent in women, and 20 to 34 from 35 to 44. However, when it can occur, the illness is often more lethal in younger women than in older people. Researchers aren't sure why. The researchers analyzed data from SEER, an application run by the National Cancer Institute to collect cancer research on 28 percent of the population of the United States. The study also used data from yesteryear when SEER was smaller. The research is based on data from 936,497 women who had breast cancer from 1976 to 2009. Of these, 53,502 were 25 to 39 years old, including 3,438 who had advanced breast cancer, also called metastatic or distant disease. Younger girls were the sole ones in whom metastatic disease did actually have increased, the researchers found. Dr. Archie Bleyer, a scientific research professor in radiation medicine at the Knight Cancer Institute at the Oregon Health and Science University in Portland who helped produce the analysis, said scientists had a need to confirm the increase in advanced breast cancer in ladies in america and discover whether it is occurring in other developed Western countries. aThis may be the first statement of this kind,a he said, adding that researchers had previously asked colleagues in Canada to analyze data there. aWe need this to make sure ourselves about this possibly concerning, nearly scary trend,a Dr. Bleyer said. aThen and only then are we really concerned about what's the cause, because place surely got to be certain itas real.a Dr. Johnson said her own experience led her to check into the statistics on the disease in ladies. When she was 27; she is now 44 she'd breast cancer. Through the years, colleagues and friends often introduced young women with the illness to her for assistance. aIt just struck me exactly how many of those individuals there were,a she said. Dr. Donald A. Berry, a specialist on breast-cancer information and a of biostatistics at the University of Texasa M.D. Anderson Cancer Center in Houston, said he was doubtful about the finding, though it was statistically significant, because the size of the apparent increase was so little a' 1.37 circumstances per 100,000 women, over the span of 30 years. More precise and more testing tests to identify the stage of cancer at the time of diagnosis might account for the increase, he said. aNot several women aged 25 to 39 get tested, but some do, but it only takes a few to account fully for a notable increase from in 100,000,a Dr. Berry said. Dr. Silvia H. The study was questioned by Formenti, a breast cancer expert and the chairwoman of radiation oncology at New York University Langone Medical Center, in part because while it found an elevated incidence of higher level infection, it did not get the associated escalation in deaths that might be expected. A spokeswoman for an group for young females with breast cancer, Young Survival Coalition, said the organization also wondered whether enhanced diagnostic and staging checks may explain all or part of the increase. aWeare taking a look at this knowledge with caution,a said the speaker, Michelle Esser. Amazement donat want to invite anxiety or alarm.a She said it was very important to note that the results applied simply to women who'd metastatic disease during the time of diagnosis, and didn't indicate that women who already had early-stage cancer experienced an elevated threat of advanced disease. Dr. J. He was said by leonard Lichtenfeld, deputy chief medical officer of the American Cancer Society, and an for the society thought the increase was real. Amazement want to make certain this isn't oversold or that people suddenly get very nervous that we've a huge problem,a Dr. Lichtenfeld said. aWe donat. But we're concerned than we have today.a that with time, we might have an even more serious problem
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