Wetting Wellness Brief a' DPRTube

That Wetting Wellness Temporary – DPRTube is created on My ABDL Life Good wetting movie of the Wellness Brief Adult Diapers from Diaperfagg. When you arrive at 1:08 in the video are you planning to here a very weight farted noise. So i wont you to be ready for that sound. But I am hoping that you planning to like what you see. You can ordered the Nasa … Keep on reading »

Papua's politics, a case of 'homo homini lupus' - Jakarta Post

Papua continues to be plagued by violence. Last month gunmen shot at an army helicopter, as the military was to evacuate victims of an ambush which killed eight soldiers and four civilians. Activists say the solution lies in a mediated comprehensive dialogue, but the government rejects any attempt to revisit history. The Jakarta Post's Prodita Sabarini reports on the political dynamics after a visit to Wamena in Jayawijaya regency.Going home: Soldiers carry the body of one of the victims of an ambush at Sentani airport, Feb. 24. Authorities said the military wing of the Free Papua Movement (OPM) attacked soldiers and civilians in Sinak in Puncak regency and Tingginambut, Puncak Jaya regency. Eight soldiers and four civilians died in the attack. (Antara/Anang Budiono)Describing the violent political situation affecting his people, a young indigenous Papuan man quoted a Latin saying: Homo homini lupus.

"Man is a wolf to [his fellow] man," said Demianus Wasage, 28, a Papuan from the Yali tribe. The provinces of Papua and West Papua are Indonesia's part of New Guinea, a resource rich, bird-shaped archipelago north of Australia. The region has a history of social unrest and has been home to rampant military abuses since part of it officially became part of the country in the early 1960s. More than four decades later, and after being given special autonomy status, the provinces remain gripped in a spiral of violence, with external and internal discord permeating Papuan politics.

Demianus was born in a rural village in what is now Yalimo regency. He said that earlier generations still practiced cannibalism when he was growing up. He wore the koteka, Papua's penis gourd, until he was in elementary school. He said he was glad that missionaries brought Catholicism to his village when he was growing up, so he did not have to follow the ancient practices he disagreed with.

He was proud of his traditional garb, which he sometimes used when accompanying foreign tourists in Papuan villages. "I'm not ashamed of wearing a koteka, I'm proud of my culture," he said.

Many Papuans believe that their black skin and Melanesian culture distinguish them from the Malay majority in Indonesia. Academics say gradual preparations for Papuan independence by the Dutch in the 1950s also developed a Papuan sense of nationhood. But the US, eager to stave off Soviet influence in Indonesia, brokered a New York agreement between the Dutch and Indonesia in 1962 that officially transferred Papua to the control of the Indonesian government. What is widely believed to have been a sham of a referendum in 1969 stopped short of any chance of Papua being recognized as an independent territory by the United Nations. Demianus said that Papuans were not included in the negotiations that decided their fate. "Even until the end of time, Papuans will always want to be free," he said.

In February this year, an attack by the Free Papua Movement's (OPM) military wing, the Papua Liberation Army Front (TPN), killed eight Indonesian soldiers and four civilians in Puncak and Puncak Jaya regency, strongholds of the TPN, authorities said the attack was the latest incident in four-decades of sporadic fighting between the Indonesian Military (TNI) and Papua's rebels.

Human rights defender Theo Hesegem from the Justice and Human Rights Advocacy Network said that OPM personnel hiding in the jungle viewed the military and the police as their enemies.

"They [the Indonesian security forces] are armed and the OPM are armed too," he said. "But [...] whether people passing by are soldiers, construction workers, or business people, as long as they have straight hair the OPM sees them as Indonesians and shoots at them," he said.

According to Indonesian Institute of Sciences (LIPI) researcher Adriana Elisabeth, unlike the former Free Aceh Movement (GAM), which had a centralized command, the OPM is fragmented into several guerrilla groups and small organizations. The organization is heavily based on the tribal identities of the leader and members.

Yulianus Hisage, the Baliem area head of the Papuan Indigenous Council (DAP), an organization of customary and tribal leaders that advocates for indigenous rights and Papuan culture, said studies showed that Papua had around 250 ethnic tribes. "In reality there's more than 300," he said.

Relations between tribes in Papua were complex, Yulianus said, with conflicts settled through tribal warfare. In the Baliem Valley alone, in the mid highland region, a hotbed for OPM guerrillas, there are 14 tribal alliances.

In 2011, when the third Papuan People's Congress was held, declaring Papua and West Papua independent from Indonesia, the congress appointed DAP leader Forkorus Yaboisembut as president. However, Lambertus Pekikir, an OPM/TPN leader in Keerom regency, Papua Province, did not acknowledge the congress. Forkorus is now imprisoned for treason and three people were killed during the authorities' crackdown on the congress.

More moderate groups gathered under the Papua Peace Network (JDP) believe that dialogue is the key to peace in Papua. The LIPI's Adriana said that for this to work, the Indonesian government should first halt its military approach to the provinces. Theo said international mediation was required to resolve the issue. "If it's just Indonesia, the odds [for resolution] are slim. We're talking about ideology. Indonesia wants a unified Indonesia, while Papuans want independence. The dispute would never end," Theo said.

Amid a lack of cohesion in Papuan communities, the National Committee for West Papua (KNPB), an independence campaign movement led by young Papuans, has emerged as a formidable component, with strong connections to the Papua independence movement overseas. Catholic priest and award-winning human rights activist John Jonga said the group was "Quite a brilliant movement".

"They have a lot of creativity, they can gather people together and they are very firm in their stances. It's clear they have overwhelmed the government — especially the military and the police — because their number is huge," John said.

Melianus Wantik, a self-styled touring ambassador for the KNPB, said that the organization was born after seeing the Papuan independence movement lose its leader with the assassination of Theys H. Eluay, who was the leader of the Papua Presidium Council in November 2001.

"The KNPB was born because we saw that Papua needed a rational political leader. Not someone who is factional, egoistic and doesn't stand with the grassroots," he said.

In its heyday, the KNPB organized independence rallies across the Papua region, with thousands of people — many in traditional garb — taking part. Their grass roots campaign in 2011 was connected to the Free West Papua campaign led by British-based Papuan exile Benny Wenda, and the rallies coincided with an international conference of parliamentarians on Papuan independence.

"Our connection with Benny is very strong. We work based on his instructions with the International Parliament for West Papua and International Lawyers for West Papua," Melianus said.

But since the killing of KNPB leader Mako Tabuni, the organization has adopted a low profile in rallies. In 2011, Papua was wrought with cases of violence that the police dubbed as being perpetrated by "unidentified assailants".

A spate of killings in June and August 2011 saw more than 20 people killed. The police have linked the violence to the KNPB and have said they would use the 2003 Terrorism Law against those attacking police stations. However, Melianus said there was no evidence and the allegations were only aimed at discrediting the movement.

Human rights activists have criticized the police's heavy-handed approach toward KNPB members. KNPB leader Victor Yeimo reported that in 2012, 22 KNPB members had been killed. Papua Police chief Insp. Gen. Tito Karnavian has defended the Terrorism Law in Papua by saying that it was required to ensure that criminals did not hide behind veneer of the freedom movement.

Benny recently toured Australia, New Zealand and the Pacific island countries to rally support for Papuan independence. But in Papua, the KNPB held no rallies. "We should have shown support because every time Benny visits these countries, we should go on the street and rally, but our room for democracy is blocked. The Indonesian government sees us as terrorists, [guilty of] treason and separatism. Our room for movement is shrinking," Melianus said.

Catholic priest John said that in Jayapura, during Mako Tabuni's leadership, the KNPB sometimes used intimidation so that people would join the rallies. "In Jayapura, they forced Papuans to follow them. Sometimes it involved beating people. Some journalists were not only intimidated but also beaten," he said.

But John strongly doubted that the killings and bombings in Papua were linked to the KNPB. "They're the ones who are getting shot at," he said.

John, who has served in Papua for more than 25 years, said that Papuans wanted independence. "This spirit of independence is supported by social and economic problems, violence, violations of human rights and indigenous peoples rights, as well as the exploitation of resources. So in meetings, they express that," he said.

The priest also spoke of another big problem plaguing the provinces — the corruption of local Papuan politicians. Since Papua received special autonomy (Otsus) status in 2001, only indigenous Papuans are eligible for regional head positions in the provinces.

The government has so far disbursed Rp 30 trillion (US$3.08 billion) in Otsus funds to West Papua and Papua provinces to speed up development. But more than a decade later, Papuans remain the poorest in Indonesia. The Supreme Audit Agency (BPK) found that Otsus funds of Rp 66 billion in 2010 and Rp 211 billion in 2011 were unaccounted for.

According to John, pro-independence Papuans must also face their own political elites that are benefiting from their current positions as regional heads. "A small number of people will feel that their finances or positions are being threatened. If their main concern is their own welfare, then these people might even kill their own people," he said.

John said that in Indonesia, people supported and opposed Papuan independence for various reasons. "But Papuans themselves say that whatever happens, be it famine or civil war, these are problems that can be dealt with later," he said. "So, the future is full of question marks."

Managing diabetes - Montana Kaimin

Clark Vowell recognized the symptoms, but he didn't want to face the reality. He thought of himself as a healthy 16-year-old kid — a little skinny, sure, but not one with a serious disease.

"I only thought diabetes came from eating too much sugar and bad food," Karen Vowell said, after her son Clark told her he might have diabetes. "He started losing weight and looked like a skeleton. We knew he wasn't a druggie."

Diabetes is a disease in which the body does not produce or properly use insulin, a hormone necessary to convert sugar, starches and other food into the energy needed for daily life.

Type 1 diabetes, or T1D, is an immune disorder in which the body attacks and destroys insulin-producing beta cells in the pancreas. In Type 2 diabetes (T2D), the body either does not produce enough insulin, or the cells ignore the insulin.

The symptoms Mrs. Vowell noticed in her son were those of T1D. While Type 2 diabetes can be prevented, controlled and even cured with a healthy diet and exercise, Clark's condition is genetic and, for now, incurable.

Tuesday marked the 25th Annual American Diabetes Association Alert day, a reminder for the public to take a test to determine if they are at risk for developing diabetes. According to the American Diabetes Association (ADA), seven percent of the U.S. population is living with this disease.

The number of Americans with diabetes has continued to increase, according to the Center for Disease Control's most recent National Diabetes Fact Sheet. So has the number of Americans with prediabetes, a condition that increases their risk of T2D, heart disease and stroke.

"When you think diabetes and type one, you think some things are over," Mrs. Vowell said. "Buts it's just a different lifestyle – you don't need to watch every little rock or crevice."

"If anyone could lead the way in this, it is Clark," Mrs. Vowell said. "From the beginning his learning curve was ahead of mine as he began to ask himself what to do to handle this disease."

Mrs. Vowell watched as her son learned how to check his sugar levels, watch how many starches he ate and take insulin. She said that for family members who have discovered their loved ones have diabetes, support is always important.

"Gauge the person's personality and play it to their strengths," she said. "Fortunately, Clark kind of did this on his own."

As many as three million Americans may have T1D, according to Juvenile Diabetes Research Foundation International, a research center looking for a cure for T1D. The Foundation also reported that each year more than 15,000 children and 15,000 adults are diagnosed with T1D in the U.S. Only five percent of diabetes diagnoses are a case of T1D, according to the American Diabetes Association (ADA).

Before Vowell finally went to the doctor, he suspected that he had diabetes thanks to WebMD. For a while, Vowell said he was constantly drinking water and going to the bathroom – a symptom of the disease, according to the ADA.

After a family ski trip, Vowell said he knew he couldn't wait any longer. He went to the doctor, and although the results were somewhat expected, Vowell said it was still scary.

Vowell stayed a few days in the hospital and immediately began to learn how to live life with diabetes. He said he soon realized that although he had many new responsibilities, life didn't have to turn completely upside down.

Vowell said you learn to check your blood sugar and how much insulin you need to take when eating a bagel compared to chips. As long as someone learns how their body will respond to certain foods, he said, there are hardly any limits.

"Ultimately, it's an individual's responsibility to manage their diabetes, but you can take the good with the bad," Vowell said.

After being diagnosed, Vowell discovered what he wanted to do with his life. Vowell said he wants to finish pharmacy school and help others manage their diabetes – maybe later even help research for a cure.

Until then, Vowell said he will continue to live life to the fullest – and use his diabetes to do so. A few years ago he completed the Tour De Cure, a 100-mile bicycle ride that raises money for the ADA. Though his blood sugar dropped once or twice, Vowell said he was completely in control of his diabetes.

During the summers, Vowell has also participated in camps for children diagnosed with diabetes, where he builds on his passion for helping people face diabetes head-on.

Vowell laughed as he talked about advising others to make diabetes a good thing, and said it might sound weird to some.

"I know not everyone who gets diabetes will be affected like I have, but those who get it do have to try to make a good out of this bad," Vowell said. "It's just my life now."

Carla Cox, a Certified Diabetes Expert, said someone diagnosed with T1D would learn that it is very livable but tedious. Life can be pretty normal but they have to remember to get insulin, check their blood sugars and count carbs when they eat, Cox said.

While this keeps someone with diabetes safe and well educated on what they consume, carb counting can have negative side effects, including eating disorders. "Someone can definitely begin to obsess about it," Cox said, citing eating disorder rates as high as 14 percent of diabetics in some regions.

Cox said T1D can result from a combination of someone's genetic makeup and a circumstance that can make someone more vulnerable – such as a virus like the chicken pox.

A case of this can be seen with Grayson Mohr, a sophomore at the University of Montana. In 1998, Mohr was one of about 5,000 people in a three-week span to be diagnosed with T1D, he said. Doctors told the Mohr family that there had been so many diagnosed, they believed a virus had triggered it.

A few weeks before starting kindergarten Mohr and his family went on a camping trip. One afternoon, Mohr drank a water supply that was intended to last three days. His mom recognized the signs and took him to a diabetes clinic the next day. Soon after, the family confirmed he had T1D.

"A person from the diabetes clinic came over for dinner and to make sure we were doing okay," Mohr said. "I remember hiding under my parents' bed for like an hour and a half because I was scared to take my shots."

With the help of his parents' goofy Band-Aids and reward system, Mohr said he adjusted to life as a diabetic pretty quickly.

Mohr said that just last week he woke up around 12:30 in the morning feeling sick and realized his insulin pump had run out. Mohr tried to walk upstairs to his roommates, but he vomited and had to wait until morning to get help.

Mohr said it had been about nine or ten hours since he had insulin in his system. This had happened several times in his life, but Mohr said that particular instance was beyond anything he had experienced before.

"I called in a roommate and said, this doesn't look okay, I was throwing up blood and I had never done that before – this one was a special occasion," Mohr said.

"I actually think I was incredibly lucky to get diabetes," Mohr said. "Just because I look around in the world and what people have sometimes – diabetes is pretty damn easy – at least I'd rather this than something else."

Statement jobs large rise in cancer survivors - Vitals

By Maggie Fox, Senior Author, NBC Media More and more individuals are enduring cancer, as a result of a brand new statement and better treatment, and earlier recognition out Wednesday projects the ranks of cancer survivors may increase by very nearly a third over the next a decade. Thatas the good news. The bad news: these 18 million cancer survivors are likely to cost a lot to the health program of money. aThe increase in the number of survivors will undoubtedly be due primarily to an aging of the people. By 2020, we expect that two-thirds of cancer survivors will be age 65 or older,a states Julia Rowland of the National Cancer Institute, which conducted the study. The NCI says 13.7 million people had survived cancer and were still living in the U.S. At the time of Jan. 1, 2012. Very nearly two-thirds of these were considered "cured,a having lasted five years or maybe more. Forty percent had survived 10 years and 15 percent had lived 20 years past their examination. aOver another decade, the number of individuals who have livedAfive years or more after their cancer diagnosis is estimated to increase roughly 37 per cent to 11.9 million,a Rowlandas team writes in the journal Cancer Epidemiology, Biomarkers & Prevention. Patients with some cancers have an especially rosy view. aFor patients with prostate cancer, we have a not quite 100 percent five-year survival rate, and breast cancer has made remarkable strides as well, with five-year survival increasing from 75 percent in 1975 to almost 89 percent in 2012,a said Rowland. ID cancer risk is helped by related: New gene discoveries aHowever, we demonstrably must have better diagnostic tools and better treatments for lung cancer.a five years Only 15 per cent of lung cancer patients stay, mainly as the symptoms are so vague that individuals aren't usually recognized until it has spread. The large development in survivorship is partially driven by better solutions. A larger issue is the aging of the citizenry, the report says. Many studies demonstrate that cancer patients rarely come back to full, completely health. The surgery, radiation and chemotherapy that will save their lives has a toll on their bodies, raising the chance both for 2nd cancers and for other conditions such as cardiovascular disease. aThe growing citizenry of cancer survivors can put pressure on a healthcare system where cancer drug shortages are increasingly common and the demand for oncology companies is positioned to outpace the way to obtain oncologists,a the scientists create. aThe increasing number of older survivors also gift ideas an original problem to the health system since older cancer survivors are far more likely to have multiple chronic illnesses and tend to experience poorer physical functioning than younger survivors.a Meaning a lot of expense. aBy 2020, it's believed that population growth alone can elevate annual costs of cancer care by 27 percent,a the experts wrote,A quoting a review in the Journal of the National Cancer Institute. aAmong children who are several year post-diagnosis, annual healthcare expenditures are twice that of the typical population, suggesting that the financial burden of cancer with regards to medical expenditures is both substantial and persistent.a Cancer may be the No. 2 cause of per year death in america, after heart disease, Akilling more than 500,000 people. Linked stories:

Link: To Boost Facebook for Your Self-Worth?

Review: SimCity (PC) - diehard gamefan

One of my brothers once belonged to a computer club in the 1980s. This club was dedicated to the Amiga (Only the Amiga Makes it Possible) and one of the big scoops they came across was a soon to be released game named: SimCity. I fell in love with that game nearly twenty-five years ago (1989). Soon "Sim" branded games were being churned out, but SimCity captured my heart. Can the rebooted franchise from the EA controlled Maxis live up to the franchise's legacy, or is this another The Sims brand extension?

You are the mayor of a town and are tasked with making the town grow. To this end, you control zoning, road building, industrial concerns and most every other aspect of general city establishment one can think of off the top of their heads. That's the story, more or less. Bribes, coke-filled orgies, gambling debts and dead hookers are not involved… or so they say. Basically, you write your own story – mine usually involved the aforementioned things.

Maxis spent quite a bit of time making and modeling Sims to live in your city. The cars, trucks, Sims, trains, weather, tornadoes and meteors come alive with fury and lively colors. Color is the name of the game as zoning depends on the classic green for residential, blue for commercial and yellow for industrial. In addition to those color coded jewels, levels of happiness, utilities coverage, density and a myriad of other charts need colors only modern computers can provide! Actually, more numbers shown in a better way would do wonders instead of graphs, charts and colors. SimCity can be pretty, but rendering all these items takes away from the best part of SimCity – running a city!

I hate Simlish or what ever the name of their dumb language is and I am glad I can mute things. The music is ok; nothing to write home about. Ambient noise and sirens from appropriate services help the atmosphere. You won't miss anything if you decide to listen to music though.

(I have one thing I have to get off my chest immediately: allow me to change servers after I log into one. Having to exit out to pick a new server is rather annoying. Now then, let's start the show.)

Let me tell you the tale, or tales to be honest. The very first city I built was known as Fun Town. I found the need to connect to the big freeway a tad annoying, mainly due to the limited size of cities. When you begin the game, you'll see a cut along the dashes style white outline (or a really poor chalk outline if you want to be morbid). That is the entirely of space you get to build your city on. Nevermind that some of it may be mountainous or comprised of water. No, you only get this much land and must connect to this arbitrarily placed large road before you can begin.

Hindered by a this bottleneck solo opening, and restrained by a rather annoying land limitation, I dropped my power plant and sewer pipe in the corner I could reach cheapest. See, since there are different road options, you have to watch your beginning dollar amount carefully. Spend too much on roads that can be upgraded those that can handle a massive amount of traffic? You'll be skint in no time. Try to take the cheap route? You'll be uber congested. What a great plan! Another choke point decision early in your city's life is that no one has even moved in and you're already having to adjust plans for congestion and population.

Oh, and the sewage? It pollutes the ground (of course), which has consequences. You see, you also have to take care of water. Unlike previous SimCity games, you don't have to lay down power lines or water lines. However, your water supply can become polluted easily, meaning that you'll eventually have to found your water supplies in different places until you can upgrade to a water treatment plant. You're beholden to the water table so, not only do you have to make sure your sewer is far away from folks (so they won't complain about the stink), you also have to judge whether or not you can afford the loss of the available water underneath the pipes. You'll eventually suck the water dry and lower the amount you gain. Therefore if you pollute precious aqua, you're screwing yourself over (kind of like how you did by buying this game… but more on that in a bit).

As I expanded my cities to the limits allowed, I found the need to be online to save (coupled with the lack of an undo button), led to either leaving not well enough alone or bulldozing entire city blocks. ****** City was ravaged, left in shambles because one block needed to have better roads thanks to massive congestion. Essential services could not save lives, stop crime or fight fires thanks to little old ******** running to the Asbestos Pajama plant to get factory rejects. I get that some features always need online gameplay (supposedly), but full on punishment like this does no one any good. This is so frustrating, especially to perfectionists who want well laid out roads but end up with a mess due to a snap point messing up.

As my solo play went on, I found that the budget just didn't keep up with the pricey features folks wanted. Why did my city, ****** City on **** Island (along with its sister city Pound Town), need so many police officers just because gambling happened to be its main source of income? Sure, I get that gambling attracts ne'er-do-wells, but my casinos actually sucked. They rarely brought in cash. Later, I learned casinos must be placed near the entrances of your city, or else they won't get traffic.

The aggressive usage of land, coupled with the amount of land you have, makes pre-planning so important. You can't just expand, expand, expand – you have to take into consideration just where you are expanding, as well as what you are going to do once you are able to build new, better facilities. For instance – my sewage pipe made a large section of Hookertown a brown mess (two dimes gets you a lot in Hookertown), but when I built a sewage treatment plant, I was told they weren't necessary. I 'dozed them (all the cool kidz say 'dozed) and placed more industry there. I had to save a large chunk of land, in advanced, to make sure I had room for the plant. I couldn't have it near my Sims (whose primary form of entertainment seemed to be protesting outside City Hall). Oh no, these Sims are too good for poop smell. Hoity-toity bunch of namby pambies! Instead, I placed it close, but not too close, to my new water treatment facility. This bordered my train station and new, higher class casino. This was my third or fourth game and I finally learned that I will be stuck having figure out a way to process poop without disturbing the precious Sims who wander about like nincompoops everywhere. While somewhat enjoyable, this means you can build yourself into a corner rather easily.

The control set up is fine, with pictograms instead of words and representations of the buildings listed. This helps when you need to see all the new goodies that become available once your Town Hall expands. Once you expand your Town Hall, you can build additions and unlock new, better utilities and civil services. Upgraded facilities would have been fantastic for Hookertown if, at the time of my multiplayer, they were shared amongst the players. Each building has four upgrade slots and, by not having sharing enabled, I was forced to use all of mine on what was tantamount to necessary infrastructure. Instead of working on taxes, I had to get transportation and emergency services. My Sims would not get educated either, since the other two upgrades were already spoken for.

The UI is clean, self explanatory and perfectly functional. It's everything else that crumbles due to ineffective game parameters. At launch, EA had six or seven servers, I forget. Why do I forget? Because I couldn't get into any of them unless it was between midnight and 4am Pacific Standard Time!. This always on requirement basically prevented me from playing the game. I had to wait for ages to be able to go in and try the damnable thing.

There are Achievements (aka the Chlamydia that has overtaken all of gaming), but I can't be arsed to look them up. There's a screenshot of them. Man, this game sapped my will to live. I played it as an automatic action. I wonder if Will Wright is done with game creation after the Spore debacle? So much promise, so much crap. I hate this. I thought Fight Club was bad, but I expected that game (for the original Xbox) to be a heaping pile of rubbish. This is SimCity. This is a game series that made city planning fun. I wanted to have fun… I wanted fun! GIMME FUN YOU DAFT BASTARDS!

Ahem… I was all set to write a humorous look at SimCity, but this game made me hate Maxis. Even The Sims couldn't do that. Thanks EA/Maxis! You guys are awful and I hope you get double hemorrhoids.

While there are a myriad of stories to be told in the SimCity, most of them end the same: being unable to pick up where you left off or being disconnected from your game. Time and time again did **** City, **** Island, and Giveupville try to soldier on in the face of constant interruption. None of them pressed on.The thing is, I wanted to play more. I put in upwards of twenty hours to give this game a fair shake. There were times where I felt there could be something more in this game. There are possibilities – new cities to build, new regions to try. You can specialize in something different the next time around or use a different street layout. All of this goes out the window when you're prevented from playing due to server load or having to always have an internet connection. Sometimes you have to restart because of a disaster wiping out hours of work.Why would you want to keep on going when you're getting your head shoved in the toilet. Either you're a co-dependent or into some water closet play. I'm not judging, I'm just saying that I'm not with you on either count.

One minute you're seeing a budget surplus and folks are happy. The next, you're suddenly losing people and traffic is a monster. Trying to find the sweet spot in making sure every need is met can be fun when there's more transparency. In SimCity, you just have to go by what you're told and believe your actions will placate the masses.

When you build a casino town, you're going to find out that crime will constantly outstrip your police unless you devote a bloated amount of your budget to police coverage. Fires? Those are caused by dumb Sims who don't know how not to start fires. You're going to need to get them educated so they won't play with matches (seriously).

How is it balanced that the basic idea of "not starting fires" isn't an inborn trait in most Sims? Why are there thousands of workers but only a fraction of them have jobs? (This was later surmised to be the work of phantom sims beefing up the population count).

SimCity gives you an idea of how to make sure all your plates are spinning well, but then tosses that out the window at some points. The game feels undercooked.

The idea of regional hubs with cities specializing adds a new twist to SimCity… in theory. In practice, the times I played multi-player, the perks of different cities did not become available to their region mates. The Great Works and specialization options are intriguing. There are some good ideas here, but the execution… yeah…

There are elements of SimCity that lead one to believe they'll be playing for quite some time. The promise of open-endedness that is assumed with the series is one. The other is the possibilities opened up for multiplayer experiences. However, in its current state, SimCity is too broken to do anything other than break any spell possibly cast on a player. Server disconnects, regional sharing not working, traffic AI issues – they all work against giving the game another chance. SimCity is the bath salts of video games. You may get hooked, but eventually someone's face is going to be eaten.

SimCity veterans will be turned off by the small city size and always on DRM requirement… oh and constant disconnects. New players may be turned confused by the entire concept… and the constant disconnects. Players on the fence can be left wanting by the constant disconnects. In essence – EA made a game that has universally no appeal. There's just not enough good to outweigh the bad when it comes to playing this game.

The botched release really hurt this game, and it isn't as if this game had much going in its favor. It took me ages to be able to even play the damn thing, only to get booted off the server and stuck waiting for twenty minutes. The inane, have to wait to bypass tutorial that tries to start on every server, the utter lack of foresight into the launch, the nanny state against players disguised and lauded as "multi-player features", the DLC that could be had if you bought the Special Super Ultra Limited Amazing Hyper Fighting featuring Virtua edition 2 with Matching Service edition even though there was already a digital deluxe edition.

More and more of EA/Maxis's lies have been exposed. You can read more about them all across the Internet (I recommend Rock, Paper, Shotgun's amazing coverage). Basically, if EA said it, it probably was a lie. The continued existence of The Sims bringing elements of that game along for the ride… the list can go on but really, this is a giant steaming heap of feces.

Short Attention Span Summary:Lies, damned lies, and pre-order hype. SimCity 2013 is a game that could have been fun, but is pretty much digitized poop with apologists (both paid robots and Maxis talking heads) saying this was their vision. I don't think any studio sets out to make the worst game ever… except for Color Dreams. Avoid this game until it hits the bargain bin.

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How researchers are fighting lung cancer using PageRank - GigaOM

Google's PageRank algorithm has forever changed the way we access information by putting the best stuff first, and now researchers are using the same mathematical models that Google uses to fight the spread of lung cancer within the human body. While there's no "best" when it comes cancer cells, the aim is to identify tumors more likely to metastasize and then hit them with targeted treatment before the cells have a chance to spread.

The researchers — who come from the University of Southern California, Scripps Clinic, the Scripps Research Institute, the University of California, San Diego Moores Cancer Center and Memorial Sloan-Kettering — combined autopsy data from 163 cancer cases (all from before the advent of radiation therapy in order to analyze the natural spread) with applied mathematics in order to carry out their study. What they found, according to a press release about the research is that

metastatic lung cancer does not progress in a single direction from primary tumor site to distant locations, which has been the traditional medical view. Instead … cancer cell movement around the body likely occurs in more than one direction at a time.

Moreover, they found certain organs tend to spread cancer cells more aggressively, while others tend to act as sponges for cancer cells. These sponge organs might still grow tumors, they just don't disperse the cells.

The mathematics involved here — called Markov chain models — are similar to what Google uses to determine what web pages are the highest-quality for any given search query. Only whereas Google uses the number and quality of links to determine the probability of a web surfer landing on any given page, these researchers are trying to predict the PageRank of tumors, if you will. So, generally speaking, a kidney would likely have a higher PageRank than a liver because the kidney is more likely to spread cancer cells throughout the body (or, in web-search terms, generate a lot of links to itself).

As data volumes proliferate and relationships between data points become more complex, Markov models are actually becoming pretty popular. Netflix uses them in order to predict the movies users will want to watch next.

The weighted connections between various states or web pages or whatever someone is ranking are often expressed as the nodes and edges of a graph. Graphs, of course, have become part of the everyday web lexicon thanks to the various social graphs and interest graphs that analyze who we're connected to (and how) and the types of topics we browse online.

So in the end, perhaps, the most-important contribution of the worldwide web won't be the revolution in terms of how we access information, but the web's function as a proving ground for advanced statistical methods starring very large and complex data sets like those found in the medical world. Already, for example, another group of medical researchers has used a Markov variant in order to create a model they think can prescribe better treatment plans because it analyzes the costs and patient outcomes usually associated with a given treatment for a given symptom.

Last year, a group of Swiss researchers developed an algorithm that, having access to a relatively small amount of data, can track anything from Twitter rumors to disease outbreaks back to their source. A company called Syapse uses the graph structure to chart the relationships among words across different medical specialties.

One would also be remiss in ignoring the computing and data-storage innovation spurred by the web that has improved our ability to handle massive amounts of genetic and other data. As the lung cancer researchers explain in their paper:

One of the strengths of such a statistical approach is that we need not offer specific biomechanical, genetic, or biochemical reasons for the spread from one site to another, those reasons presumably will become available through more research on the interactions between CTCs and their microenvironment. We [have created] a quantitative and computational framework for the seed-and-soil hypothesis as an ensemble based first step, [that] then can be further refined primarily by using larger, better, and more targeted databases such as ones that focus on specific genotypes or phenotypes, or by more refined modeling of the correlations between the trapping of a CTC at a specific site, and the probability of secondary tumor growth at that location.

The long story short is that the more data we have and the easier we can analyze and map it, the better we can treat — and perhaps even cure — cancer and other complicated diseases.

Feature image is a network map of how lung cancer spreads between organs, where each numbered node correlates with a specific organ.

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Ziopharm cancer drug fails late-stage trial; shares plunge 66 percent - Yahoo! News (blog)

(Reuters) - Ziopharm Oncology Inc said it will stop developing its drug to treat soft tissue sarcoma after it failed to improve patient survival by keeping the cancer from worsening, wiping out nearly two-thirds of the company's market value.

The drug, palifosfamide, was being tested in a late-stage trial called Picasso 3 as a treatment for metastatic soft tissue sarcoma - a type of cancer of the bone, cartilage, fat or muscles.

"We know that based on (the) progression-free survival (rate), there is no way the drug will get approval anywhere in the world," Chief Executive Jonathan Lewis said.

An independent committee recommended that the patients be followed to test the improvement in their overall survival, but the company said it does not expect to continue the follow-up.

Brinson Patrick Securities analyst Vernon Bernardino said the company's decision to stop the drug's development was "drastic" but noted that the company had "burned" a lot of money on the project, and would probably need to raise money later in the year.

As a part of the review, it will convert another ongoing study - testing the drug as a treatment for small cell lung cancer - into a mid-stage trial, CEO Lewis said. Ziopharm began the study, called Matisse, in June last year after completing an early-stage trial.

Analyst Bernardino said the move to convert the Matisse study into a mid-stage trial did not come as a surprise. He said Ziopharm had expected to turn Matisse into a mid-stage study, if Picasso were to fail.

"It was rather aggressive of them to go right to a late-stage study (in Matisse) because they used early-stage data as a bridge to the late-stage trial," he said.

The company expects to get survival data from Matisse by the middle of the second half of this year, for which Bernardino said he had high hopes.

"I think it will show efficacy and definitely show safety in the trial. A mid-stage study is a lower hurdle for the company, with less risk."

Ziopharm also said it would now focus more resources on its synthetic biology program, which creates DNA-based drugs that enable controlled delivery of genes producing proteins to treat cancer.

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Diabetes Tied to Dementia in Latinos - MedPage Today

Register Today Make Free CME Credits by studying the most recent medical newsin your niche. 38062 Published: March 25, 2013 Mexican Americans under treatment for diabetes had a better threat of dementia or other cognitive impairment than their colleagues without diabetes, researchers found. Through up to decade of follow-up, patients under treatment for diabetes had about twice the risk of developing dementia or other cognitive impairment after accounting for the competitive risk of death and other factors (HR 2.05, 95% CI 1.41 to 2.97), based on Mary Haan, DrPH, of the University of California San Francisco, and peers. Though there was a similar trend seen with untreated diabetes, the relationship was not statistically significant after adjustment for the competitive risk of death (HR 1.55, 95% CI 0.93 to 2.58), the scientists described online in Diabetes Care. "Screening and treatment for diabetes that changes success among those with type 2 diabetes may affect future dementia incidence rates," they wrote, writing that death rates among patients with diabetes have declined lately. "The potential effect... will depend on the factors inducing the decrease in the mortality rate," they wrote. If the decline results from assessment and better administration of the condition, dementia rates may additionally drop, they observed. But, if the decrease in mortality rates is not a representation of paid off disease severity, "and if more dementia risk is influenced by severe diabetes,... dementia rates among individuals with diabetes might increase," they continued. Some previous studies have linked type 2 diabetes to a better danger of dementia and other cognitive impairment in older adults, but none has considered the relationship specifically among Mexican Americans, who have high costs of diabetes, poor glycemic get a grip on, and more problems compared with non-Hispanic whites. Haan and colleagues explored the problem using data from the Sacramento Area Latino Study on Aging. Participants were included 1,617 by the current analysis ages 60 to 98 (mean age 70) have been free from dementia or cognitive impairment at baseline. Follow-up survived around a decade and averaged 6.5. Over all, 41.9% of the players had diabetes at baseline or developed it during follow-up, 9.8% developed dementia or cognitive impairment during the study, and 22.3% died. The mortality rate was higher among those with diabetes (26.9% versus 19%) and those with dementia or other cognitive impairment (39.6% versus 20.4%). After adjustment for sex, education, time-dependent waist area, and time-dependent swing, there was a larger threat of death among those with handled diabetes (HR 2.15, 95% CI 1.58 to 2.95), untreated diabetes (HR 2.12, 95% CI 1.65 to 2.73), and dementia or cognitive impairment without dementia (HR 2.48, 95% CI 1.75 to 3.51). In entirely adjusted designs that didn't account for competitive risk of death, both untreated and treated diabetes were associated with risk of developing dementia and other cognitive impairment (HRs 2.38 and 1.88, respectively). The association was rendered by adjustment for the competing risk of death with untreated diabetes nonsignificant. "Those with treated diabetes within our sample have higher glucose and insulin, [a higher rate of] hypertension, and more comorbid cardiovascular disease, and may have more severe diabetes than those that were untreated," the authors observed. "This might explain why their dementia risk is greater, considering the fact that the risk of death is similar in both groups." They accepted some limits of the research, including selection bias arising from the requirement that individuals survive to at least 60 years of age, some attrition that would have biased the results, the usage of self-report to measure stroke and physical exercise, and the potential residual confounding. The study was supported by the National Institute on Aging, the National Institute of Digestive and Diabetes and Kidney Diseases, and the American Health Assistance Foundation. The authors noted which they had no conflicts of interest. Primary source: Diabetes CareSource reference:Mayeda E, et al "Type 2 diabetes and 10-year risk of dementia and mental impairment among older Mexican Americans" Diabetes Care 2013; DOI: 10.2337/dc12-2158. Sponsored Resources ADVERTISEMENT ResourcesA( from Industry) Movie Collection Medical Education (Non-CME) Most Examine Stories ADVERTISING

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47) Little Furs Productions HD Bon Jovi “Bad Medicine”

47) Little Furs Productions. Video by Pandr. Artwork by Tavi Munk. Bon Jovi "Bad Medicine". Cute Drawings like always when it comes to Little Furs Productions video whit Tavi Munks art. I hope he newer going to stop to draw this cute drawings.

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MSU's Payne inspired by cancer battle of 7-year-old friend - Detroit Free Press

EAST LANSING -- As he has transitioned from enticing prospect to burgeoning star on the basketball court, Adreian Payne's life has become the source of growing public attention -- and it's just getting started.

The Michigan State junior forward's media crowd was the biggest and stayed longest after Monday's practice, as the Spartans prepared for Friday's Sweet 16 game against Duke at Lucas Oil Stadium in Indianapolis. He talked about overcoming a learning disability and becoming the team's top upperclassman student, putting himself in position to graduate a semester early if he wants.

"Next year I will not have a full schedule like a normal senior. I could graduate early, but I wouldn't be able to play (my senior season)," said Payne, who must be enrolled to be eligible.

He talked about the loss two years ago of his grandmother, who raised him after his mother died when he was a child. He talked about his growth from a freshman who wouldn't watch film to a junior who stood up and apologized to his team after what he deemed a lackluster effort in Thursday's NCAA tournament-opening win over Valparaiso.

And he talked about a recent, major addition to his life, who also happened to be at Monday's practice. Lacey Holsworth, a 7-year-old from St. Johns who is battling cancer, was there with her family to watch practice, then spend some time with Payne afterward.

"I'm real close to them," Payne said of the Holsworths. "She calls me her big brother and I call her my little sister. We're very, very close. It's helped me build another relationship. ... It's just another thing God blessed me with, to be able to help other people."

Lacey had some back pain and was diagnosed in December 2011 with neuroblastoma, a "football-sized tumor" found in her abdomen, said her father, Matt.

About a month later, the MSU basketball team visited Lacey at Sparrow Hospital in Lansing. She immediately latched on to Payne. The two started spending time together over the summer and now text and talk regularly.

"He doesn't have a lot of family support, losing his mom and his grandma, so we do the best we can to be there to support him," Matt Holsworth said of Payne. "He's a young man with a big heart, and he's helped Lacey a lot."

Before it was removed, the tumor wrapped around Lacey's spine and left her paralyzed for a few months, but she now can use both legs again. Matt and his wife, Heather, are meeting with doctors at U-M Hospital in Ann Arbor today to determine when to schedule a needed bone marrow transplant.

Lacey has had chemotherapy and radiation treatments, but the hope is that the transplant will clear her of the cancer. Doctors are "pretty positive," Matt said, after an initial diagnosis that was not nearly as positive.

The Big Ten Network, which did a story on Payne and Lacey this season, got the family -- Lacey has three other siblings -- tickets for the Big Ten tournament in Chicago. As thrilled as she was, her presence also makes a difference for Payne.

"It gives me something other than basketball to do and think about," Payne said. "Even though I've got other family, but just helping her is, I can't even tell you. It's just something I do and I enjoy."

Payne will be a big part of MSU's push this weekend to win two games and advance to the Final Four in Atlanta. MSU coach Tom Izzo said Monday that Payne has grown "as much as any player I've had since (Morris) Peterson."

That growth includes the quest for a degree his late grandmother, Mary Lewis, badly wanted for him. That quest could keep Payne in East Lansing longer than some might expect.

"I'm very excited," Payne, who has not ruled out an early jump to the NBA, said of graduating. "I didn't ever really think I would be able to go to college and graduate when I was playing in that creek (in Dayton, Ohio) and throwing beer bottles at my brothers. So it's just ... a blessing from heaven."

Contact Joe Rexrode: 313-222-2625 or jrexrode@freepress.com. Follow him on Twitter @joerexrode. Check out his MSU blog at freep.com/heyjoe.

Tito Vilanova back at Barcelona after cancer treatment | The Sun ...

His club have released a statement welcoming him back to the Nou Camp ahead of Barca's match with Celta Vigo on Saturday.

"He left on January 21 for treatment in New York and two months later, this week, Vilanova will leave the Big Apple to return to the Catalan capital.

"During his absence, Jordi Roura took the reins of the team and was in constant contact with Vilanova, agreeing all decisions.

Diabetes: Early Lessons - WRCB-TV

"We chose fourth grade because we feel that students at that age level are responsible enough and at an age where they can absorb the message," said Doreen Garza, UTPA College of Health and Human Sciences, Border Health Office Executive Director.

"It was geared toward their attention span. It doesn't move to fast, it doesn't move to slow. All of the higher order vocabulary, like pancreas for example, is spelled out with pictures and little graphics they can relate to," said Dr. Shawn Saladin, UTPA College of Health and Human Sciences Associate Dean.

The movie wasn't the only piece of information given out. Students also took home a small coloring assignment and more importantly, a diabetes registry form to give to someone they know with diabetes.

Study finds some diabetes drugs may be related to precancerous condition - The Star-Ledger - NJ.com

A small study found people taking diabetes drugs such as for example Merck & Co.as Januvia were suffering from pancreatic cell growth. Photo is filed by associated Press People using diabetes drugs such as Merck & Co.as Januvia were suffering from pancreatic cell growth and injury that'll change dangerous, a small study found. The research, led by Alexandra Butler and Peter Butler of the University of California, Los Angeles, offers proof increased precancerous changes in diabetics using alleged incretin mimetics, Public Citizen, a public advocacy group, said in a statement today after the study was published. The Food and Drug Administration said this month it had been reviewing unpublished results by a number of educational experts suggesting precancerous cellular changes might be connected with Type 2 diabetes solutions referred to as incretin mimetics, which also include Bristol-Myers Squibb Co.as Byetta and Novo Nordisk A/Sas Victoza. aThese conclusions are in agreement with the rapidly increasing quantity of studies to the U.S. Food and Drug Administration of pancreatic cancer in individuals using these drugs compared with diabetics using different drugs,a Public Citizen said. Doctors have been concerned because the FDA said in 2007 it received a higher amount of studies of pancreatitis in patients using Byetta that this group of diabetes treatments may damage the pancreas. The firm issued an identical alert for Januvia in '09. An analysis of insurance records published last month in the log JAMA Internal Medicine revealed such drugs may possibly increase a useras risk of pancreatitis. These medicines were stopped by that hasnat from becoming multibillion-dollar drugs. An examination of pancreases from 20 diabetics confirmed a 40 percent escalation in pancreatic cells in addition to cell damage in the people treated with incretin therapy, todayas study found. Of the 20 pancreases, eight were from people using incretin therapy, while 12 were on different therapy, according to a report in Diabetes, a journal of the American Diabetes Association. Eight of the nine people getting incretin solutions for annually or more were using Whitehouse Station-based Merckas Januvia while the other was using Byetta, according to the study. The research indicated that in humans, incretin treatment resulted in amarkeda cell proliferation and injury, with a potential for progress in to cancer, the authors wrote. Merck disagrees with the studyas theory, is comfortable in the safety of its drug and hasnat viewed any link between it and pancreatitis or pancreatic cancer, Kelley Dougherty, a spokeswoman for the drugmaker, said in a statement. Shock might tell you that the FDA said a week ago that the FDA hasn't achieved any new ideas about safety risks with one of these medicines, and at this time patients should continue to simply take their medication as directed until they speak to their health care company, and health care services should continue to follow the prescribing information in the medicine labels,a Dougherty said. Januvia produced about $4.1 billion in 2012 worldwide sales, Merck has described. Ken Dominski, a for New York-based Bristol-Myers, declined to touch upon the studyas studies. For Byetta, exenatide, aan considerable nonclinical security known program was conducted to guide the marketing applications of exenatide twice daily and exenatide after weekly,a Dominski said within an e-mail. aIn those studies, exenatide government was not associated with any drug- related pancreatic tissue injury or toxicity in any species tested.a Byetta and its longer-acting model, Bydureon, had $227 million in 2012 income, Bristol-Myers reported. Victoza, also called liraglutide, is the fastest-growing product for Bagsvaerd, Denmark-based Novo, with income moving 58 per cent in 2012 to 9.5 billion kroner ($1.7 billion). The medication mimics a called GLP-1 to encourage normal insulin production. A Novo spokeswoman declined to touch upon the analysis revealed today.

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Teenage cancer deaths cut to half of what these were in the 1970s - Raw Story

By Agence France-PresseMonday, March 25, 2013 7:17 EDT Adults and nearly half as many teenagers are dying from cancer currently as did in the 1970s, in accordance with a report from Cancer Research UK revealed Monday. Deaths between 2008-2010 in this age group were around 300 a, down from 580 a year in the period 1975-1977. The largest development was in those diagnosed with leukaemia with more specialised remedies considered to be behind the decline, said the report, aCancer Statistics Report: Teenage and Young Adult Cancer.a The research unveiled that around 2,100 people aged 15-24 years old are clinically determined to have cancer annually in Britain. aItas great to see such a drop in how many young adults dying from some types of cancers during this time,a explained Simon Davies, leader of Teenage Cancer Trust. aHowever, many of the rarer cancers which affect young adults like sarcomas have made little or no improvement. aMore investment in unusual cancer study is urgently needed,a he warned.

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Free diabetes screenings set - Suffolk News-Herald

Editor's note: This is another in a series of stories leading up to the American Diabetes Association's Tour de Cure in Suffolk on April 20.

Diabetes Alert Day is coming up next week, and the American Diabetes Association is urging everyone to find out if they are at risk or have already developed the disease.

Type 2 diabetes affects nearly 175,000 people in Hampton Roads, including about 53,000 who do not even know they have it. An additional one in three American adults has pre-diabetes.

Diabetes Alert Day, a project of the American Diabetes Association, is Tuesday. A free screening will be held in Suffolk for folks to find out their risk.

"Part of our mission at the American Diabetes Association is for people to know their risk for Type 2 diabetes," said Robin Kantor, a manager at the organization's South Hampton Roads chapter. "A lot of people wait until they have a complication — blurry vision, neuropathy in their feet — and that brings them to the doctor. At that point they already have a complication that isn't reversible."

Type 2 diabetes, the more common form of the disease, is caused when the pancreas does not produce enough insulin, a hormone that helps the body process sugar, or when the cells ignore the insulin. It differs from Type 1, which is caused when the pancreas stops producing insulin completely.

It is important for people to know their numbers to determine their risk factors for diabetes, Kantor said. High blood pressure, cholesterol and weight contribute to diabetes. Risk increases with age and lack of physical activity. Race is also a factor, with any race other than white being at increased risk. Men are at higher risk than women, but women who were diagnosed with gestational diabetes are at higher risk than those who were not. One of the best predictors of risk is family history, so people should know whether a biological parent or sibling has been diagnosed with diabetes.

"Studies have shown that Type 2 diabetes can be prevented or delayed by losing just seven percent of body weight (such as 15 pounds if you weigh 200) through regular physical activity (30 minutes a day, five days a week) and healthy eating," said Dr. Joseph Aloi, clinical director at Eastern Virginia Medical School's Strelitz Diabetes Center.

Tuesday's free screening — from 2 to 7 p.m. at the Suffolk Family YMCA, 2769 Godwin Blvd. — will test cholesterol and blood pressure, as well as A1C and blood glucose, which are indicators of whether a person is diabetic or pre-diabetic. Those tests will be provided by Eastern Virginia Medical School, while Bon Secours Hampton Roads Health System will provide body mass index tests, along with information on diabetes care.

The American Diabetes Association will hand out information on healthy living, along with resources available through the association.

"If you score a five or higher, it lets you know it's time to go to the doctor and get your A1C checked," Kantor said.

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Is Cancer Contagious? Could Hugo Ch��vez Have Been Deliberately Infected? - Scientific American

The late Venezuelan president implied that his enemies gave him cancer. Katherine Belov, an expert on transmissible cancer in Tasmanian devils, says that is unlikely—but not impossible

CANCER Pancreatic cancer cells, false color scanning electron micrograph Image: Anne Weston, LRI, CRUK. Wellcome Images

Venezuelan officials announced this week that they would investigate whether enemies could have deliberately infected late President Hugo Chávez with cancer. Chávez died on March 5, apparently of a heart attack, after battling cancer for two years.

When the former Venezuelan president was diagnosed with an undisclosed form of cancer in 2011, he speculated that his enemies could have given him the disease. He also implied that U.S. agents could have developed a technology to induce cancer, according to a CNN news story at the time. The U.S. State Department called the accusation "absurd."

The theory that someone could be infected with cancer is not biologically impossible, but it is unlikely. A healthy immune system will combat any foreign cells, including cancerous ones. Only three types of contagious cancers have been identified, and all occur in non-primates.

Scientific American spoke with Katherine Belov, professor of comparative genomics at the University of Sydney who studies a contagious cancer called Tasmanian devil facial tumor disease. She explains why contagious cancers are rare and whether cancer could infect another person.

What are contagious cancers?In humans, we know that you can catch viruses, like the human papillomavirus, which make you more likely to get cancer. [HPV can cause cervical cancer in women, and genital warts and anal cancer in men.] In humans, environmental causes play an important role, too—cigarette smoke and radiation exposure can cause cancer. However, we don't have any clear examples of [naturally occurring] transmissible cancers in humans.

There is a transmissible cancer in dogs. It's a sexually transmitted disease called canine transmissible venereal tumor, or CTVT. And there is also the Tasmanian devil facial tumor disease, which I work on. The devil's cancer causes large ulcerations in their mouth and around their jaw. When they fight—and they fight a lot—they are biting other animals, and the cancerous cells are implanting in other animals' wounds.

In both the Tasmanian devils and in the case of CTVT, the tumor evolved in really inbred populations of animals. There was a lack of diversity and so the cancer is genetically very similar to the animals it passes to.

Why does lack of diversity help the cancer jump from animal to animal?The cancer is transmitted to animals that are genetically similar to one another and also to the tumor. The immune system doesn't "see" it and doesn't mount an immune response. The cancer can then grow until it kills the animal.

Over time the devil's facial tumor disease would have encountered animals that were genetically dissimilar to it. But the cancer found a way to down-regulate [or produce fewer] cell-surface molecules, which are sort of red flags to the immune system in genetically different animals. These flags are part of the major histocompatibility complex [a set of molecules attached to cells that regulate interactions with immune cells]—they are MHC molecules. Without those special immune molecules the cancer is able to fly under the radar of the immune system and pass from animal to animal.

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Mining consumers web searches can reveal unreported side effects ...

Researchers at the Stanford University School of Medicine and Microsoft Research have revealed that the Internet search history of consumers can yield information on the unreported side effects of drugs or drug combinations.

By analyzing 12 months of search history from 6 million Internet users who consented to share anonymized logs of their Web searches for research purposes, the team was able to pinpoint an interaction between two drugs that was unknown at the time of data collection.

"Seeking health information is a major use of the Internet now," said co-author of the new paper Russ Altman, MD, PhD, Stanford professor of bioengineering, of genetics and of medicine. "So we thought people are likely typing in drugs they are taking and the side effects they are experiencing and that there must be a way for us to use this data."

The goal of this and previous research is to find fast, accurate methods of determining when a drug or combination of drugs cause unexpected side effects in some patients. The U.S. Food and Drug Administration encourages physicians to report any possible side effects through the agency's Adverse Event Reporting System. Such reporting is voluntary, however, and relies on a patient or a physician noticing that something unusual has happened.

Altman's lab group had previously studied whether it was possible to comb through data from FDA reports to discover drug-drug interactions in an automated way. Using their data-mining methods on the FDA reports, the group reported in May 2011 that it had found a never-before-reported side effect of combining paroxetine, an antidepressant medication, and pravastatin, a cholesterol-lowering drug. When a patient was taking both paroxetine (marketed as Paxil) and pravastatin (marketed as Pravachol or Selektine), the researchers found that the patient's risk of developing hyperglycemia — high levels of blood glucose — was greater than the risk of hyperglycemia from taking either drug individually.

Altman and his colleagues wondered whether they could have pinpointed the side effect any other way, since the adverse-event reports they relied on for the original discovery are only generated when a doctor takes the initiative and believes the side effect warrants reporting.

"Historically, it's been really hard to detect synergistic effects of drug combinations that aren't necessarily side effects of any of the drugs alone," Altman said.

Public Internet search history had previously been used to track flu outbreaks - a 2010 paper concluded that looking at the location and frequency of flu and flu-symptom-related searches was as accurate at following the flu's spread as the hospital-based-tracking methods used by the U.S. Centers for Disease Control and Prevention. To see whether a similar approach could work for detecting drug interactions and side effects, Altman teamed up with Nigam Shah, MBBS, PhD, assistant professor of medicine at Stanford. They collaborated with Eric Horvitz, MD, PhD, distinguished scientist and managing co-director at Microsoft Research; senior Microsoft researcher Ryen White, PhD, who is the study's lead author; and a colleague at Columbia University.

The Microsoft team developed automated tools for mining anonymized data from 82 million drug, symptom and condition searches performed by 6 million Internet users who had agreed, when they installed a Microsoft browser plugin, that the company could use their search history for research purposes.

White said the team used the automated tools to identify searches for information on paroxetine, pravastatin or both during 2010. The tools then computed the likelihood that users in each group would also search for hyperglycemia — or almost 80 of its symptoms or descriptors, such as "high blood sugar," "blurry vision," "frequent urination" or "dehydration."

"We really had to take into consideration this difficulty in predicting people's language," said Altman. "We could miss things because, through no fault of their own, the public doesn't know medical jargon."

Among people who searched for the drug paroxetine or its brand names in 2010, about 5 percent also searched for one of the hyperglycemia-related terms. For pravastatin and its brand names, the rate was below 4 percent. But for those who searched for both drugs, suggesting that they might be taking both drugs, the search rate for hyperglycemia was 10 percent.

To test the accuracy of the search engine analysis, the team looked at 31 drug-drug interactions already known to cause hyperglycemia, and 31 interactions known to be safe. Overall, the drugs with known interactions led to more search queries on hyperglycemia. But the results also suggested that around 12 percent of users searching for drug combinations known to have no interactions also had an unusually high rate of hyperglycemia searches, which would lead researchers down dead ends if they pursued them.

"We were surprised how good the signal was," said Shah. "The challenge now is to figure out what application this has in continuous monitoring for such side effects."

One way to improve this false-positive rate, Altman and Shah agree, is to combine the search history data with other sources of data — social media, patient support forums and information from medical records and doctors.  Shah and his team are already studying how to search in an automated way through anonymized versions of patients' electronic medical records to find drug interactions. If the mining of consumer search engine data is combined with other information — such as reports to the FDA and searches by doctors on professional medical search programs — it could provide lists of potential drug-drug interactions for researchers to look into more closely through traditional clinical trials, they say.

"If we cross-reference multiple data sources, then we can triangulate based on what doctors and patients are both concerned about," said Shah.

The search data will always be messy, Shah admitted, since an Internet user's search history doesn't tell the complete story. Users could perform one search on their own symptoms, and the next on a symptom or drug related to someone else in their household, for example. In addition, a news story on a known or suspected drug-drug interaction could lead to excessive searches on that side effect, artificially inflating the results. But even if the data are messy, he said, enough messy data — like millions of search records — can reveal directions for researchers to pursue.

"I believe patients are telling us lots of things about drugs, and we need to figure out ways to listen," said Altman. "This is just one way of listening and one application."

The study was funded in part by the National Institutes of Health (grants HG004028 and GM61374). Information about Stanford's Department of Medicine, which also supported the work, is available at http://medicine.stanford.edu.

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How exactly to Start Losing Weight the Balanced Way

calories, fats, fat loss, Weight Loss Journal The best way for you to slim down has nothing to do with crash dieting and it's nothing to do with bursts of sudden workout. Your body wants changes that are slow as it pertains to how you consume and how you exercise. For example, if you have not practiced in a while then it'd be unwise for you to rush into managing a hundred miles each day or totally pounding that treadmill. Not just are you going to struggle to achieve this, nonetheless it is going to help you hurt yourself instead of help you shed weight or treat your body right. The key to slimming down the proper way and the healthier way is always to take it slow. Here are some things for you to consider. - * Your system uses the food that you consume to provide it with power. It stores any remaining excess energy inside you as fat. Than your system really needs then what this means is that if you are eating more food you are going to achieve weight without even meaning to. - * For you to lose excess weight you are going to have to burn up the fat storage. Both most effective techniques you can perform this are to cut back just how many calories you are eating in one day, and to increase the body's natural levels of activity. - * It is quite crucial that you introduce your changes on a gradual level. Small changes can definitely add up to be able to make a truly big difference in your lifetime. Reduce small things out of your daily diet and add small exercises and right away flat you will be seeing some truly serious changes that you did not previously realize that you were effective at. - * Increasing your activity levels is quite crucial. You're still likely to slim down, if you increase how much exercise you're doing while maintaining the exact same diet. Even if you hate gyms, there are exercises that you may do to over come your weight problem. A 20 minute walk every day can definitely make all the huge difference as an example. Find something which you enjoy doing. Find something which is simple for you to do. Get right up and take action. It really is that simple. The more effective that you're, the more calories you will burn, whether you cut calories from the diet or not.- * Still another key is to commit things to report. Write your plan down on paper, write down on paper what you eat and write down what you do when you exercise and when you exercise and for just how long. When you make things like this to paper, it makes them more true, and it makes you get your aims more seriously in the act. Photograph Credits: Laurel Fan Initially posted 2009-11-04 03:26:25. Republished by Blog Post Supporter Categories: Tags:

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What sort of Healthier Heart May Reduce Danger of Cancer - TIME

Spirits and tumors may actually share more in accordance than we think. Following heart-healthy tips may also protect you from cancer, in line with the study from the American Heart Association (AHA). Eating a wholesome diet, exercising and keepin constantly your weight have long been ways to fend off heart disease, but scientists at Northwestern University Feinberg School of Medicine in Chicago report in theAjournal Circulation that following a AHAas Lifeas Simple 7 ways to lessen heart disease may also cut cancer risk. The Lifeas Simple 7 include: (MORE: Fruits Associated with Lower Cardiovascular Disease Among Women) Scientists examined the health records of 13,253 white and African-AmericanAmen and women who were mixed up in Atherosclerosis Risk in Communities Study, which followed the participantsa health results and the eight risk factors since 1987. At the beginning of the research, the volunteers were examined andA surveyed about which healthier habits they followed. Two decades later, the researchers examined hospital records and cancerAregistriesAand discovered that 2,880 of the members were identified as having cancer of the lung, colon or rectum, prostate and breast. Those who were recognized, however, tended to follow along with less of the Lifeas Simple 7 behaviors than those who didn't develop cancer. People who followed six of the seven health measurements had a lower cancer risk than the members who did not meet the steps. The connection held even after the scientists accounted for the result of smoking on cancer risk; when smoking was taken out of the situation, players who used five to six of the health ways had a lower cancer risk. (MORE: For Greater Heart Health Workout Tougher, Perhaps not Longer) aThis enhances the human body of research indicating that it's never late to change, and that if changes are made by you like improving your diet and quitting smoking, you can reduce your risk for both cardiovascular illness and cancer,a said cause study authorALaura T. Rasmussen-Torvik, an assistant professor at the Northwestern University Feinberg School of Medicine in a statement. Thatas welcome, and useful information amid the current sea of confusing and contradictory data about preventing serious illness. In cases like this, the information is actually very simpleAa' specific healthy habits, such as for instance eating foods low in fat, sugar and calories, and exercising regularly, can reduce your risk of two of the main killers of American adults. aThere are many health messages shown in the popular press and frequent (and often contradictory) accounts of novel risk factors for disease,a Rasmussen-Torvik and her colleagues write. Consumers are sometimes confused by athese messages, leaving themAunsure on the most crucial measures to take for disease prevention. Hopefully that focusing a unified technique fromAmultiple chronic disease advocacy groups, promoting someAcommon methods for disease prevention, is likely to be particularlyAeffective in aiding the general public to avoid chronic disease.a MORE: A Happy, Positive View May Protect Your Heart

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Developments in diabetes treatment: Better results, lower cost - Wake Forest University News Center

Published: A March 18, 2013 By Alicia Roberts Office of Communications and External Relationships When Jeffrey Katula and his research colleagues attempt to determine when they may help prevent people from developing diabetes applying group-based problem solving, he didnat expect such drastic results. By the end of the two-year undertaking, called the Healthier Living Partnerships to Prevent Diabetes (HELP PD) Study, the participants had lost comparable quantity of weight and developed comparable reduced fasting blood-sugar levels as participants in an earlier benchmark research a' which cost not quite 3 x just as much. The effects of the study, aThe HELP PD Study: 2-year outcomes on fasting blood glucose, insulin, and adiposity,a appear online in advance of print book in the American Journal of Preventive Medicine, along with a cost analysis of the program. The project was supported by way of a grant from the National Institute of Kidney Diseases and Digestive and Diabetes. A multidisciplinary team of researchers from Wake Forest University, Wake Forest School of Medicine and Wake Forest Baptist Health, led by principal investigator Mara Vitolins of the medical school, conducted the research. aTraditional behavioral weight loss programs rely a lot on training a how to exercise, how to see food labels,a said Katula, associate professor in the Department of Health and Exercise Science and lead writer of the paper. aOur system decreased the emphasis on didactic knowledge and instead focused on a problem-solving, empowerment-based design. Participants talked about what things were getting back in the method of slimming down, they worked as an organization to establish approaches to overcome the barriers.a The outcome was that HELP PD participants lost an average of nearly 13 pounds, and held it down within the 2 yrs of the study; weight loss is just a crucial aspect in controlling and preventing diabetes. And because the program was implemented at the grass-roots level by community health workers in local recreation centers, the price of the attention was $850 per person. In the research, the Diabetes Prevention Program, cost of care was $2,631 per person. The cost would be brought by aa new, effective, low-cost treatment for diabetics and pre-diabetics down significantly for a massive risk to U.S. and global publicAhealth,a said Michael Lawlor, director of the Health Policy and Administration Program in the Department of Economics and lead author of the HELP PD cost-effectiveness report. In early March, the American Diabetes Association estimated the sum total expenses of identified diabetes, including hospital inpatient care, medicines, diabetes items, medical practitioner office visits and nursing facility stays, had risen to $245 billion annually in 2012. The ADA last noted annual costs of diabetes in 2007, when the total was $174 million. SUPPORT PD hired over 300 members who were led through the weight-loss plan by community health workers (CHWs) a' citizens who had a history of healthful lifestyles and well-controlled diabetes. The CHWs were paid a minor amount a' $100 per week to lead weekly conferences for the first 6 months, and then $200 a month for the rest of the study. They certainly were trained by authorized experts in the community, and had hardly any connection with researchers or other high-level authorities. Amazement desired to utilize as much existing community resources and systems as you are able to, and reduce steadily the part of study resources and study personnel,a Katula said. Shock desired to know, could we accomplish that which was achieved in the original research at a lower cost? Don't assume all community has access to a diabetes detective a' therefore could we produce a program that could work in just about any community in the united kingdom, even without access to expertise?a The investigation team is currently testing the plan in five county health departments in Vermont to determine if money can be saved by Medicaid applying this model. aThe Medicaid program could be enthusiastic about growing reimbursement for diabetes prevention programs to community health workers,a Katula said. aIf we could help more people prevent developing diabetes, it'd reduce steadily the need certainly to purchase diabetes treatment down the line.a

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Poll: 1 in 8 clinically determined to have diabetes - Springfield News-Leader

A astonishing one in seven Americans has been identified as having diabetes, a new Harris Interactive/HealthDay ballot indicates. And multiple third of these questioned have been diagnosed with diabetes or have a parent, cousin, spouse or child with the condition. aType 2 diabetes is becoming among the most typical and fastest growing illnesses. Fully one in seven adults a' approximately 29 million people a' now report that they have been diagnosed with this hazardous condition,a said Harris Poll Chairman Humphrey Taylor. Included Dr. Ronald Tamler, clinical director of the Mount Sinai Diabetes Center in Ny City: aDiabetes is quite dangerous. You donat know youare in trouble until the complications hit or until itas therefore out of control you have uncontrolled urination and thirsta a' two of the most popular outward indications of diabetes. While diabetes is happening in epic proportions, the new study also unearthed that knowing of the disease is still remarkably minimal, with only 21 percent of those surveyed considering themselves well-versed on the disease. Meaning the rest of the 79 percent may not know theyare at an increased risk or may curently have the condition, which is known as the asilenta killer. But people previously diagnosed with diabetes are generally much more aware of the health threats, with somewhat more than two-thirds considering themselves both aextremelya or averya knowledgeable about the disease, the poll found. However, 35 percent of respondents with diabetes said their diabetes was only asomewhata controlled and 5 percent said it was anot at alla well controlled. aBecause diabetes is really a chronic condition, the treatment of that will be critically determined by patient behavior and self-care, this may be probably the most disconcerting finding,a Taylor said. On an even more encouraging note, lots of people polled do understand that a number of factors could contribute to type 2 diabetes, including being obese (79 percent of respondents recognize it is a risk factor), diet (74 percent) and physical inactivity (62 percent). (Page 2 of 2) These numbers were higher among people who was identified as having diabetes. Curiously, 60 % of respondents realize that genetics could be a part of type 2 diabetes. Many people, if they have diabetes or not, seem pretty experienced in the long-term consequences of the disease, that may include amputation of limbs, blindness, kidney disease and heart disease, the poll found. There is an exception. 56 percent of these with diabetes and only 39 percent of people over all knew that the condition can cause strokes. aPeople need to be aware that this really is yet another disease brought on by diabetes that can be prevented,a said Nancy Copperman, director of Public Health Initiatives at North Shore-LIJ Health System in Great Neck, N.Y. aThe idea of having a stroke may possibly stimulate them to change their lifestyle.a The disease appears to be taking a toll on these interviewed, with 20 percent admitting it's been a burden and 43 percent saying it's been asomewhata of a for themselves and their loved ones. The duty comes in the shape of medication charges, dietary restrictions, attention problems, cardiovascular problems and foot problems. Additionally, 9 percent of people with type 2 diabetes said the condition has rendered them unable to work.

Application available for cancer research - Newsandtribune

> SOUTHERN INDIANA a More than 650 citizens in the Louisville and Southern Indiana places have signed up for an opportunity to be involved in a future traditional research that has the potential to change the experience of cancer for future generations, but the American Cancer Society is pushing for more. And now, 1 week away from the big event, the others are urged to sign up today to take part in theA in order that canceras biggest mysteries could be revealed. Men and women involving the ages of 30 and 65 who've never been diagnosed with cancer are needed to be involved in the American Cancer Societyas Cancer Prevention Study-3 (CPS-3) in Louisville and Southern Indiana. The goal is to help researchers better comprehend the lifestyle, environmental and genetic facets that cause or prevent cancer. The chance for local citizens to sign up in CPS-3 is being made possible in partnership with the American Cancer Society, Baptist Health Louisville (previously Baptist Hospital East), Floyd Memorial Hospital and the YMCA of Southern Indiana a Clark County Branch. An appointment can be scheduled by participants by going to cps3kyin.org or calling 1-888-604-5888. Also, registration will need place at various places in Louisville and Southern Indiana a few weeks. In Southern Indiana, they are: Floyd Memorial Hospital, 1850 State St., New Albany, 3 to 7 p.m. Tuesday, March 19, and 7 to 10:30 a.m. Wednesday, March 20; and YMCA of Southern Indiana a Clark County Branch, 4812 Hamburg Pike, Jeffersonville, 4:30 to 7 p.m. Thursday, March 19, and 7 to 10:30 a.m. Thursday, March 20. At the application appointments, individuals will undoubtedly be asked to read and sign an educated consent form; complete a detailed review packet that wants informative data on life style, behavioral, and other factors related to your health; have his/her waist circumference measured; and provide a blood sample, in accordance with a cancer society launch. Upon completion of this process, the society will point regular follow-up surveys to update data and annual updates with research improvements and effects. The registration process takes approximately an hour to perform. Regular follow-up surveys of various measures are anticipated to be delivered every few years to individuals. Researchers will use the information from CPS-3 to create on evidence from a set of American Cancer Society reports that began in the 1950s that collectively have involved millions of volunteer members. The Hammond-Horn Study and previous Cancer Prevention Studies (CPS-I, and CPS-II) have played a significant role in understanding cancer prevention and risk, and have contributed significantly to the scientific basis and development of public health guidelines and tips. These studies established the link between lung cancer and smoking cigarettes, confirmed the link between larger waist dimension and elevated death rates from cancer and other causes, and showed the significant impact of smog on lung and heart problems. The present research, CPS-II, started in 1982 and remains on-going. But changes in lifestyle and in the understanding of cancer in the more than two decades since its introduction make it very important to begin a new research. The voluntary, long-term commitment by participants is what will create benefits for many years ahead. Visit cps3kyin.org to learn more.

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Boy battle cancer is helped by bball clinic - Fox11online.com

Updated: Saturday, 16 Mar 2013, 6:42 PM CDTPublished : Saturday, 16 Mar 2013, 6:42 PM CDT APPLETON - A baseball hospital in Appleton was about more than teaching children some new skills. It absolutely was also about helping others. Fourteen-year-old Jordan McCabe published Saturday's event at the Appleton Alliance Church.AMcCabe spent your day training hundreds of kids how exactly to dribble, complete and manage a ball. Beyond training new skills, McCabe arranged the big event to greatly help out Braeden Jansen, 6, who's struggling Leukemia. McCabe said it's been good to see the community come out to aid Jansen and his family. "It really feels good to know that the community generally speaking is really, they feel, attached to him, and feel that they might help him. And if they might help him, and if they are gonna do that even occasionally of importance of some body, then that's actually good," said McCabe. About 300 young ones participated in the case. All of the money raised should go to Jansen and his family.

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Lahey Hospital and Clinic writes cookbook for cancer patients... - Boston.com

The following was published by Lahey Health: Keith Stuart, MD, mind of Oncology at Lahey Hospital & Medical Center, Burlington, Corrine Zarwan, MD, and the staff at the Sophia Gordon Cancer Center are very happy to mention the writing of The Lahey Clinic Guide to Cooking Through Cancer: 100+ Recipes for Treatment and Recovery to help individuals choose recipes and foods that may help relieve their symptoms and make dealing with cancer easier. aCooking through Cancer was a task that many people at the Sophia Gordon Cancer Center at Lahey Hospital & Medical Center, Burlington, kept near to our hearts,a said Dr. Stuart. aCancer therapy is quite hard on your body. The illness, combined with the unwanted effects of treatment, can make it extremely difficult for individuals to get foods which are tasty. This book was designed by us to help patients find great foods they can enjoy together with their families all through an otherwise hard time.a The book contains over 100 healthy and delicious recipes which are enjoyed by cancer patients and can be prepared by indicator, as well as their families. The recipes might help with a number of cancer treatment side effects, such as for example weight gain, constipation, diarrhoea, nausea, and sore mouth and loss. The book also includes a acelebrationsa section, for their disease has been overcome by those who, or those who merely desire to celebrate how far they've come in their treatment. Each formula in the book was tested and approved by Drs. Stuart and Zarwan, in addition to a staff of Oncology doctors, nutritionists and nurses. Readers can make up from Mediterranean split pea soup (to help with weight gain prevention), constipation, and sore mouth to roast pork loin with root veggies (to help with vomiting and constipation and sickness). Several symptoms are combated by many recipes at the same time. aThe goal of the book is always to help patients discover the enjoyment of good food that cancer often reduces for them,a Dr. Stuart said. aWhile food will not cure cancer or drastically change its course, it can certainly make remedies simpler to weather.a Drs. Stuart and Zarwan will be hosting a signing function at the Barnes & Noble in Burlington, Mass., on March 1 to celebrate the launch of The Lahey Clinic Guide to Cooking Through Cancer. A percentage of the proceeds from this book will undoubtedly be provided to the Sophia Gordon Cancer Center, so visit to get your signed copy and help support this cause. For more information about the book or just how to obtain it, please visit: Lahey.org/CancerCookbook. About Lahey Health Lahey Health is whatas next in healthcare providing a full continuum of integral health services near in your geographical area or work. It is made up of nationally-recognized, award-winning hospitals a including an academic hospital and clinic, and group hospitals -- primary care providers, consultant physicians, behavioral health services, post-acute programs such as for instance home health services, skilled nursing and rehabilitation facilities, and senior care sources located throughout northeastern Massachusetts and southern New Hampshire. Lahey Health gives more than 1,200 locally-based physicians providing clinical quality and a fantastic individual expertise in adult and pediatric primary care and every medical specialty, including kidney and liver transplantation; cancer, cardiovascular and orthopedic medical and surgical care; local emergency and stress care; urological surgery; chronic disease prevention and health management; and pediatric emergency, newborn and inpatient care provided in cooperation with Boston Childrenas Hospital physicians. Lahey Health includes Lahey Hospital & Medical Center -- a hospital of Tufts University School of Medicine -- and Lahey Clinic physician team with techniques in Burlington, Peabody and other locations throughout northeastern Massachusetts and southern New Hampshire. Beverly Hospital; Addison Gilbert Hospital in Gloucester, MA; Lahey Health Senior Care and Lahey Health Behavioral Services along with over 30 primary care physician practices and satellite specialty and numerous hospital care facilities. Together, we're making modern, integral health more personal and more accessible. To learn more, visit LaheyHealth.org and its member websites Lahey Hospital & Medical Center, Beverly Hospital, and Lahey Health Behavioral Services.

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