Register Today Make Free CME Credits by studying the most recent medical newsin your niche. 38062 Published: March 25, 2013 Mexican Americans under treatment for diabetes had a better threat of dementia or other cognitive impairment than their colleagues without diabetes, researchers found. Through up to decade of follow-up, patients under treatment for diabetes had about twice the risk of developing dementia or other cognitive impairment after accounting for the competitive risk of death and other factors (HR 2.05, 95% CI 1.41 to 2.97), based on Mary Haan, DrPH, of the University of California San Francisco, and peers. Though there was a similar trend seen with untreated diabetes, the relationship was not statistically significant after adjustment for the competitive risk of death (HR 1.55, 95% CI 0.93 to 2.58), the scientists described online in Diabetes Care. "Screening and treatment for diabetes that changes success among those with type 2 diabetes may affect future dementia incidence rates," they wrote, writing that death rates among patients with diabetes have declined lately. "The potential effect... will depend on the factors inducing the decrease in the mortality rate," they wrote. If the decline results from assessment and better administration of the condition, dementia rates may additionally drop, they observed. But, if the decrease in mortality rates is not a representation of paid off disease severity, "and if more dementia risk is influenced by severe diabetes,... dementia rates among individuals with diabetes might increase," they continued. Some previous studies have linked type 2 diabetes to a better danger of dementia and other cognitive impairment in older adults, but none has considered the relationship specifically among Mexican Americans, who have high costs of diabetes, poor glycemic get a grip on, and more problems compared with non-Hispanic whites. Haan and colleagues explored the problem using data from the Sacramento Area Latino Study on Aging. Participants were included 1,617 by the current analysis ages 60 to 98 (mean age 70) have been free from dementia or cognitive impairment at baseline. Follow-up survived around a decade and averaged 6.5. Over all, 41.9% of the players had diabetes at baseline or developed it during follow-up, 9.8% developed dementia or cognitive impairment during the study, and 22.3% died. The mortality rate was higher among those with diabetes (26.9% versus 19%) and those with dementia or other cognitive impairment (39.6% versus 20.4%). After adjustment for sex, education, time-dependent waist area, and time-dependent swing, there was a larger threat of death among those with handled diabetes (HR 2.15, 95% CI 1.58 to 2.95), untreated diabetes (HR 2.12, 95% CI 1.65 to 2.73), and dementia or cognitive impairment without dementia (HR 2.48, 95% CI 1.75 to 3.51). In entirely adjusted designs that didn't account for competitive risk of death, both untreated and treated diabetes were associated with risk of developing dementia and other cognitive impairment (HRs 2.38 and 1.88, respectively). The association was rendered by adjustment for the competing risk of death with untreated diabetes nonsignificant. "Those with treated diabetes within our sample have higher glucose and insulin, [a higher rate of] hypertension, and more comorbid cardiovascular disease, and may have more severe diabetes than those that were untreated," the authors observed. "This might explain why their dementia risk is greater, considering the fact that the risk of death is similar in both groups." They accepted some limits of the research, including selection bias arising from the requirement that individuals survive to at least 60 years of age, some attrition that would have biased the results, the usage of self-report to measure stroke and physical exercise, and the potential residual confounding. The study was supported by the National Institute on Aging, the National Institute of Digestive and Diabetes and Kidney Diseases, and the American Health Assistance Foundation. The authors noted which they had no conflicts of interest. Primary source: Diabetes CareSource reference:Mayeda E, et al "Type 2 diabetes and 10-year risk of dementia and mental impairment among older Mexican Americans" Diabetes Care 2013; DOI: 10.2337/dc12-2158. Sponsored Resources ADVERTISEMENT ResourcesA( from Industry) Movie Collection Medical Education (Non-CME) Most Examine Stories ADVERTISING
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