Cornerstone Helps Train Doctors So that you can Diagnose, Treat Lupus - NY1.

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Our immune systems are designed to protect us from microorganisms, bacteria and viruses, but especially those with the auto-immune disease lupus, experience something completely different.

"Your immune system turns upon you, so it's attacking every organ from your body or every tissue of one's body, potentially: your middle, your lung, your minds, your kidneys, " shows Margaret Dowd, the executive director of the SLE Lupus Foundation.

It took Nono Osuji a few months of medical visits, tests and outright worrying before doctors learned that was what ended up being happening in her entire body.

"At that time, I am like covered in rashes, my hair is receding, I'm burning, I'm never sleeping. I'm fatigued, nevertheless, " Osuji says.

Since her diagnosis a couple of years ago, Osuji has volunteered with the SLE Lupus Foundation, accommodating bring more awareness with the disease that many times targets women like her.

It was subsequently Osuji's purple-colored rashes on her behalf skin, which have left scars behind on her behalf arms, that helped clinical professionals diagnose her when your lady was 28. But don't assume all person gets rashes and the inflammation she expert.

Thanks to federal dollars and many partners, SLE's Lupus Homework Institute created the Lupus Gumption, a program designed to better train doctors and medical researchers about the disease, with the objective of greater early detection.

"The curriculum is incredibly thin in medical colleges, both for lupus in addition to autoimmune disease, " Dowd tells. "One very well-known lupus physician told me, 'If you sleep within a morning in med the school, it's unlikely you'll ever be capable of know about lupus. '"

Osuji still struggles along with the disease, but she says knowing that it must be lupus at work has empowered her to get proactive about her well being.

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Psych Out there: Episode 2: Diapers? – Online video.

Created by and starring Evalina Turpin Filmed and Edited by Danny MAlin It's relay a crazy story of a girl that have panic for diapers and go to a psychologist about it. I bet that you can figure out what's going to happen in the end from this movie? Yes she is going to be …

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Hyperlink between war support along with PTSD, time it later part of the in negotiations and courtship by narcissists.

Militia returning home from combat can be at a heightened risk for developing post-traumatic stress and anxiety disorder if public support in a war effort is cheap, according to recent homework. Social validation or invalidation shapes the level of distress soldiers feel with the act of killing, a researchers say. The study involved a few experiments that asked participants to exterminate woodlice in the modified coffee grinder – in a single, having an actor express either interest or disgust for the act and in another, asking participants to record who agreed to the extermination and exactly who refused. In both cases, the conditions that socially invalidated the killing of the bugs led to far more distress and guilt one of many participants. Ironically, the research workers report, the very anti-war protests geared towards eliminating show support for soldiers but disdain for combat may increase the likelihood that returning soldiers experience mental distress. "How Social Validation and Invalidation Change the Distress of Preventing, " David Webber (dwebber[at]ualberta. ca) et ing., Personality and Social Mindset Bulletin, April 2013.

Good negotiations come to those who wait Procrastinating may be a good thing on the subject of the negotiating table, based on a new study. While experts have suggested that making the first offer is an vital negotiation tactic, the timing of that first offer is simply as critical. Making a first provide late gives negotiating parties more of their time to explore underlying interests so to consider novel solutions – producing more creative agreements in addition to conflict resolution, the study workers found. "Good Things Arrive at Those Who Wait: Tardy First Offers Facilitate Inspiring Agreements in Negotiation, " Marwan Sinaceur (marwan. sinaceur[at]insead. edu) et 's., Personality and Social Mindsets Bulletin, June 2013.

Do narcissists woo women with less effort? Narcissists do have a less severe time attracting a mate, according to new homework. In one experiment, researchers asked 61 men to get out on the street in the large German town and to each approach 25 women we can generally like to arrive at know to try to get contact information for as many islands as possible. Those male participants who ranked an excellent source of personality evaluations of narcissism collected the foremost contact information. The researchers found that those men who had been successful also ranked great for physical attractiveness and community boldness. "Are Narcissists Hot? Zeroing in on the issue of Narcissism on Short-Term Spouse Appeal, " Michael Dufner (dufnermi[at]googlemail. com) et al., Personality and Social Psychology Bulletin, published online May 2, 2013 – on the web, July 2013.

Virtuous people are not universally happy Increasingly being good, or virtuous, and being happy often can be equated, but new research finds that going barefoot depends on where you result from. In countries where antisocial penalising your pet is common and at which people commonly justify shady behavior, virtuous individuals (measured, for example, by how comfortable folks are avoiding a fare concerning public transport or cheating on the taxes) are not as pleased with life compared to even more selfish individuals. The analyze, which involved surveys greater than 100, 000 individuals, viewed antisocial punishment in 13 international locations and dishonest behavior around 73 countries. For case study, in Denmark and the country, virtuous individuals are pleased than their less virtuous counterparts, while in Greece, and Russia, they can be less happy than their own more malicious fellow locals. "Are virtuous people happy on world? Civic virtue, antisocial penalising your pet, and subjective well-being upon cultures, " Olga Stavrova (stavrovo[at]uni-koeln. de) et 's., Personality and Social Therapy Bulletin, published online September 23, 2013 – on the internet, July 2013.

Distance issues when politicians speak with issues When politicians speak to their constituents them selves turf, they should work with specific examples to bolster their arguments, according to help you new research. Whether on the main topic of gun control or homeland protection, study participants were more likely to support politicians located near them if they reported specific examples and were more likely to support politicians located afar if he or she spoke in general, even more abstract terms. For example, participants read supposed interview responses from their congressional representatives located varying distances off them that either offered the Gabrielle Gifford's aiming case in Arizona or simply spoke about gun influence more broadly. "How Do We end up needing Others to Decide? Geographical Distance Influences Evaluations of Decision-Makers, " Erin Burgoon (eburgoon[at]utexas. edu) et al., Personality and Social Mindsets Bulletin, June 2013.

George Bonnano of Columbia University studies loss and injury, including from natural catastrophes, such as the recent tornadoes inside U. S. Midwest, together with following terrorist attacks, for example the Boston Marathon bombings. She's available by email: gab38[at]columbia. edu

Roxane Cohen Silver within the University of California, Irvine, studies working with loss and resilience subsequent collective traumas, also among them natural disasters and terrorist blasts. She is currently working away at an NSF-funded study concerning aftermath of the Boston ma Marathon bombings. She is accessible by email and mobile phone: rsilver[at]uci. edu

SPSP encourages scientific research that explores the way in which people think, behave, come to feel, and interact. The Society is very large organization of social and personality psychologists on the earth.

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'Previvors' stopped breast cancer before it started by having breasts removed - New York Daily News

Once Ackerman, 39, from New City, N.Y., learned she also carried the BRCA gene, which carries a very high risk of cancer, she decided to have surgery.

"It was a no-brainer," said the mother of three. "I wanted to be around for my kids, hold my grandchildren, stick around for a while."

She underwent a double mastectomy at Greenwich Hospital in Connecticut, followed by a flap reconstruction, where a surgeon used fat and blood vessels from the lower abdomen to rebuild the breasts.

"Why stick your head in the sand?" she asked. "I hope my daughter chooses to get tested when she's 18 so that she can make an informed decision."

Vanessa Silva-Welch, an administrative assistant at Frederick Douglass Academy in Harlem, got tested for the BRCA gene after her father was diagnosed with breast cancer in 2007.

Then a 32-year-old mother of three, she was shocked to learn that not only had she inherited the ticking time bomb, but she was already in the early stages of breast cancer.

"I want to live a long time. I want to watch my kids grow up and see my grandchildren," said Silva-Welch, now 38, who opted for a bilateral mastectomy at St. Luke's-Roosevelt Hospital.

"I didn't want to hear later on down the road that my cancer came back," said the upper West Sider. "I told myself that my breasts do not define who I am as a woman."

It took Silva-Welch a year to fully recover from the surgery and reconstruction, as well as from the chemotherapy she took alongside her dad to eradicate any remaining breast cancer cells.

"I still do have the constant reminder about my scare because the scar is there, but I still feel like I'm living a regular life and nothing's changed," she said. "I'd rather have my breasts gone over having cancer."

"This was absolutely terrifying," said the 55-year-old mom from Westbury, L.I. "But I didn't want to wait to get cancer."

Her mother and grandmother both died from ovarian cancer, and she didn't want her 14-year-old son to suffer the same tragic loss.

"I'm not a betting woman," she said, "and once I learned the odds of me getting cancer were over 50%, I said, I gotta do this."

"The one piece of my body I was never concerned with was my breasts," mourned Stanley. "It took a long time to bounce back, but I'd rather not have breasts than have cancer."

She turned to Adelphi New York's Statewide Breast Cancer Hotline and Support Group to connect with other women who have made the same difficult choice.

"People thought I was a hypochondriac," said Brett, 49, of the upper East Side. "People didn't understand why I would do something so drastic when I didn't have cancer yet."

After losing three aunts to breast cancer at a young age, and watching her sister and six cousins all get diagnosed with the big C, Brett wasn't taking any risks. Once she learned she was BRCA1 positive — like Angelina Jolie — she went under the knife.

"People are very opinionated about it," she said, "but unless you have that mutation, and you know you have an 85% to 87% chance of getting cancer, and you've lost someone close to you, you don't know what it's like."

"I had a 2-year-old son and I wanted to make sure I would be there for him when he's 20," she said. "It's a pretty simple choice when it comes down to it."

Nicki and Ally Durlester say it's no surprise Angelina Jolie chose Dr. Kristi Funk at the Pink Lotus Breast Center in Beverly Hills for her prophylactic mastectomy.

The mother-daughter duo are also patients of Dr. Funk, and both share the same "faulty" BRCA gene that drove Jolie to surgery.

Mom Nicki Durlester tested positive for the gene in 2001, was diagnosed with stage 2 breast cancer in 2009 and avoided chemotherapy by having both breasts removed.

"Dr. Funk saved my life," the 56-year-old author from Sherman Oaks, Calif., told the Daily News. "She walked in the room and just slayed the doom and gloom. She has an undergraduate degree in psychology, so she really nails what a woman is going though with breast cancer."

Nicki's 26-year-old daughter is now prepping for the same procedure. Both women said Jolie's announcement will help immensely with public perception.

"People think you're crazy to remove body parts. … But if you knew you had an 87% chance of dying in a plane crash, would you get on the plane?" Nicki asked.

Ally said Dr. Funk recommended she get her surgery before she turned 30 because the rule of thumb is that you take the youngest age that one of your close relatives got cancer and then subtract 10 years.

In her op-ed in the New York Times, Jolie hinted that her mom was diagnosed with breast cancer not long after she turned 46. Subtract 10 from that, and it's in the ballpark of Jolie's current age, 37.

Olivia Newton-John Reveals Sister's Cancer Battle - ABC News (blog)

Rate 23, 2013 10:32am (Picture Credit: Gregory Pace/Getty Photographs) After battling breast cancer herself, singer Olivia Newton-John is coming to the aid of her older sister, who has been clinically determined to have brain cancer. The 64-year-old aGreasea star, who beat breast cancer twenty years ago, has delayed her forthcoming Las Vegas show to be with her brother, Rona Newton-John, 69. In a to Entertainment Tonight, Olivia Newton-John said she had recently obtained athe really unfortunate newsa that her cousin had been adiagnosed with mind cancer.a aIn light of this news, I have chose to postpone my approaching Vegas residency to invest time with her and our family,a Newton-John wrote. aAs a athrivera myself, as many individuals are, I'm very conscious of the value of service, love and family during this trip she is planning to begin.a See Olivia Newton-Johnas Gathering With David Travolta The Australian pop singer is delaying her concert at Vegasa Flamingo resort substituting for Donny & Marie Osmondas away times actually before tickets continue sale, in line with the Vegas Sun. Her cousin Rona was also an actress and was married to Newton-Johnas aGreasea co-star Jeff Conaway from 1980 to 1985. Their child, Emerson, 38, is really a race-car driver. Conaway, who famously struggled with alcohol abuse, showing on aCelebrity Rehab with Dr. Drew,a died in 2011 at age 60.

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Algeta is declared the winner FDA approval for new treatment of prostate cancer - Boston Globe.

Norwegian drug maker Algeta ASA, which set up a US commercial business office in Cambridge's Kendall Rectangular in September, won Food and Illegal drug Administration approval Wednesday to market a new treatment for prostate cancer that's spread to the osseins.

Algeta's drug, called Xofigo, snacks castration-resistant prostate cancer, a disease that afflicts tens of thousands of men in the United States and much more worldwide. The drug works by releasing targeted alpha-particle-emitting radiation within the bones, killing cancer cells but doing limited trouble for surrounding healthy tissue, stretching out patients' lives.

"In however long it takes, what we're trying to complete is improve the patients' total well being, " said Jeff Albers, the Cambridge-based president of the company's Algeta US division.

Algeta will comarket Xofigo to US urologists and oncologists using German pharmaceutical giant Bayer AG. Bayer, which filed the completely new drug application with the FDA in addition to with European regulators, has exclusive rights to market Xofigo outside the u . s. The drug was developed in Oslo by Algeta, that struck a partnership by means of Bayer. The parties expect the drug to get approved in Europe by year's end.

Albers, some veteran of Cambridge biotechnology firm Genzyme Corp., joined Algeta a year and a half ago. He said Algeta chose to set up its own sales force here in lieu of in Europe because "it's much easier to build a commercial footprint" available as one country. The company has on the subject of 80 employees in Norway and 80 in the united states, including about 20 in Cambridge, where its USA commercial, marketing, medical important affairs, and general operations tend to be based.

Wednesday's FDA approval came three months before the agency was scheduled to act on the US app in what already was deemed important review. In a proclamation, the agency said Algeta's treatment "demonstrates an capacity extend the survival of men with metastatic prostate cancers. " About 30, 000 die from the condition each year in the country.

Albers said the US sales arm eventually hopes promote other Algeta cancer drugs being developed in Norwegian. "Our vision is not to copromote this product, " he said. "Our vision is being a worldwide oncology company. We'll grow as time passes, but we're the right size now. "

Unfamiliar Spanking.

Remi and Sammy  as they always do every evening, playing on a basketball court that is definitely close to their home. Sammy saw that it was subsequently getting dark, with  a  little  worry  in  his  voice, he thought to his brother: " It s  late already  and  getting  dark, dad must be  angry around! Let s go home! " But when these folks were about to leave, eventually and out  of  the  blue, a significant spaceship had …

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New cancer tools allow patients to reconsider chemo - Fox News

After decades of using one-size-fits-all therapies to combat cancer, doctors are using new tools to help decide when their patients can skip chemotherapy or other harsh treatments.

An approach to oncology that has been in place for decades is beginning to yield to an arsenal of long-term clinical studies, genetic tests and novel drugs that target cancer cells and their infrastructure.

"What is happening is a combination of new technology and more-targeted cancer drugs," said Dr Sandra Swain, medical director of the Cancer Institute at Washington Hospital Center and president of the American Society of Clinical Oncology (ASCO). "We've tried the approach of big, nonspecific treatments ... We have found that throwing chemo at patients has not (necessarily) cured them."

Traditional chemotherapy drugs work by interfering with the entire body's system of cell replication, causing harsh side effects like fatigue and hair loss.

Since the completion of the human genome project in 2003, scientists have made progress in unlocking the genetic basis of a range of diseases, including cancer. That has paved the way for genetic testing as well as drugs that block specific pathways that cancer cells use to grow and reproduce.

Such targeted cancer drugs, which sometimes preclude the need for chemotherapy, are being sold by companies ranging from Pfizer Inc, the world's largest drugmaker, to Ariad Pharmaceuticals Inc, which early this year launched its first drug, to treat leukemia.

At the same time, large-scale studies that look at whether some types of patients are better off with less treatment are giving doctors more confidence to hold off on using traditional cancer drugs.

Laurie Levin, now 64, was successfully treated in her 20s for non-Hodgkin's lymphoma, but faced a dilemma after being diagnosed with breast cancer in 2005 since the earlier radiation and chemotherapy had already raised her risk of developing heart problems or leukemia.

A $4,000 genetic test showed that her breast cancer was unlikely to return, providing the confidence to undergo a lumpectomy and avoid chemotherapy.

Use of the Oncotype DX test, which analyzes genes involved in tumor recurrence, has cut the use of chemotherapy in U.S. breast cancer patients by 20 percent over the past eight years, according to its maker, Genomic Health Inc. The company recently launched a similar test designed to measure whether men with prostate cancer need to undergo surgery or radiation.

Tests and studies can clarify treatment, but costs remain on the upswing because the newest drugs are very expensive, with monthly price tags often in the thousands of dollars. By 2016 annual global sales of cancer drugs will nearly triple, to $88 billion from a decade earlier, according to IMS Health.

'RIGHT-SIZING TREATMENT'The "less is more" approach to cancer will be one highlight of ASCO's annual meeting in Chicago that begins at the end of this month. On Wednesday, ASCO released thousands of abstracts on new clinical trials of cancer treatments.

One large, long-term study found that most men diagnosed with early-stage seminoma, a common type of testicular cancer, did fine with no treatment following surgery to remove the tumors.

Cure rates for the disease have always been quite high. Several European countries, including Denmark where the study was conducted, monitor seminoma patients for any relapse before further treatment. In the United States, about half of early-stage patients are still given radiation or chemotherapy, according to ASCO.

"Opting for surveillance spares patients, most of whom are young men, from the harmful side effects of chemotherapy and radiation without diminishing their chances for a long and healthy life," said ASCO's incoming president, Dr Clifford Hudis, in a statement.

Physicians say it is difficult to quantify in statistics, but there is growing recognition that less is more in terms of potentially toxic cancer treatments. The approach is especially important for young patients who will have many years ahead of them after beating an initial bout of cancer.

"We are right-sizing treatment," said Dr. James Mohler, chair of the department of urology at Roswell Park Cancer Institute in Buffalo, New York. He pointed to recent national guidelines calling for "active surveillance" of older men diagnosed with slower-growing prostate cancer.

A study presented earlier this year at an ASCO meeting in Florida found similar survival rates for men with high-risk prostate cancer who received radiation and either 18 or 36 months of hormone therapy. The findings suggest the therapy, which causes significant side effects, could be given for less than the current standard of 24 to 36 months.

Another recent study out of the Duke Cancer Institute in Durham, North Carolina, found that survival odds for women with early-stage breast cancer who underwent breast-preserving surgery such as lumpectomy were as good as, or even better than, the odds for women who had mastectomies.

"We are going to see reevaluations of very successful therapies to determine whether or not we can achieve the same results using less treatment," said Dr Armand Keating, director of the hematology division at the University of Toronto and president of the American Society of Hematology.

The first-ever study showing that a type of leukemia could be cured without using chemotherapy was released in December. The Italian-German study found that a combination of a derivative of vitamin A, known as ATRA, and arsenic trioxide, a newer drug, worked as well as ATRA and chemotherapy in patients newly diagnosed with acute promyelocytic leukemia (APL).

"APL used to be one of the most dreaded strains of cancer, but with ATRA and chemo the results are very gratifying," Keating said. "Now we have two agents that are not chemo agents ... That to me is a milestone. I can't see any reason why this wouldn't become the standard of care."

A recent trial conducted in France found that omitting standard chemotherapy, which has been linked to heart damage, from the initial treatment of a type of childhood leukemia did not reduce survival outcomes.

"The nice thing is you have omitted a potentially toxic agent that contributes to morbidity and maybe mortality down the road," Keating said.

The priciest therapies are designed to take advantage of genetic mutations associated with cancer cells, some of them found only in a small percentage of patients.

A new drug for melanoma, BRAF inhibitor Zelboraf from Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Patients are first tested to see if they have it.

Pfizer's lung-cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients. It also has been effective as a treatment for a rare but aggressive type of childhood lymphoma.

"We've been really trying for years to be more precise about who needs treatment ... Now we are more able to achieve it," said Swain.

Via: Many Can Blame Family for Their Bunions

Modish, Anti-Science Thinking Won't Progress Breast-Cancer Prevention - Forbes

8 weeks before an organization named the Inter-Agency Breast Cancer and Environmental Research Coordinating Committee, or IBCERCC, released a 270-page report entitled updated Cancer and the Environment: Prioritizing Prevention.a The statement was the result of 8 years of lobbying by breast cancer advocates to acquire increased funding for research dedicated to prevention of the disease and the direct results of the Breast Cancer and the Environment Research Act passed by Congress in 2008.A A major force behind the statement was the National Breast Cancer Coalition (NBCC), an active organization which since 1991 has been quite effective to make breast cancer research and treatment a national goal. The 2008 bill called for the formation of the committee to draft a study detailing goals for prevention.A The cell was to consist of representatives from advocacy groups; afederal membersa from agencies including the National Institute of Environmental Health Sciences, the National Cancer Institute, the Environmental Protection Agency, the Department of Defense, and the Centers for Disease Get a grip on and Prevention; and non-federal members from the medical and clinical areas. The report, that has been couple of years in the making, did not lack for ambitious ambitions, among them: ato prioritize prevention,a ato change how research is conducted,a ato strategy purposefully across national agencies,a ato practice trans-disciplinary researchers,a and ato read and communicate science to society.a But the understanding of these high objectives was compromised by the different agendas of the diverse membership of the committee.A Some were advanced members of the advocacy movement who really thought that more could be done to find out new information that would lend itself to prevention.AA Others had a narrow plan to focus on substances in the atmosphere, whether this was highly relevant to breast cancer or not.A Some of the scientists were focused on defending their turf in the place of animal types of breast cancer.AA Finally, the bureaucrats from NIEHS and NCI were developing their particular agendas. At the core of the report is a fatal confusion between two different uses of the word aenvironment.a AAInitially the IBCERCC report defines the environment broadly to include everything that's not genetics a lifestyle and behavioral factors, such as for example alcohol consumption and physical activity; social and cultural influences; and chemical and physical agents that individuals are confronted with, including commercial contaminants, pesticides, an such like. Nevertheless, it becomes obvious early on that the major thrust was to highlight a much narrower definition of aenvironment,a specifically the essential role of contact with substances and their effects on breast tissue beginning in utero and throughout the life course. The confusion between both of these explanations proves useful to authors of the report, because most people don't stop to look at the distinction and do not know the evidence for every alternative.A Therefore the report can blur the distinction between the well-founded broad definition and the poorly-supported but far more amazing slim definition entailing experience of chemical contaminants. To support its philosophy, the report argues that exposure to aendocrine disruptorsa and other kinds of chemicals in food, water, the air, and in cosmetics and cleaning products are likely to be important contributors to breast cancer and need to be the focus of extensive, inter-disciplinary research.A (The term endocrine disruptors describes substances that have hormonal effects in dwelling organisms. )A In doing this, the report embraces studies that appear to support its claim and at the same time ignores much more thorough studies that do not support the existence of a danger. We know a great deal about breast cancer, but nearly all of what is known does not lend itself to prevention.A And so the question is, How well does the assumption that experience of substances in the environmental surroundings play an integral role in breast cancer square with what we know? Breast cancer in the usa is definitely associated with socio-economic status, i.e., with higher educational level and higher income.A In addition it occurs more commonly in Anglo women than in Latinas a' strikingly, the later group having about 30-35 percent lower incidence.A This really is most likely explained by the truth that more educated women and Anglo women are more likely to delay having children, more likely to have fewer children, and more likely to have used hormone therapy after menopause.A Many of these factors are associated with increased risk. On the facial skin of it, exposure to chemicals in the environmental surroundings will probably be LOWER in higher income women a' think about the greater exposure to traffic exhaust in lower income neighborhoods, exposure to chemicals in waste websites, as well as occupational exposures. Now letas consider the data for a role of particular substances in the environment.A The IBCERCC report focuses on BPA as a for the possible contribution of aendocrine disruptorsa in producing breast cancer.A It emphasizes that exposure to BPA is common in the general population as evidenced by the diagnosis of BPA in the urine of 95% of individuals in studies of the general population.A In addition, the report cites effects of BPA on mammary tissue in animal studies. What's striking is these answers are generally from a single group of scientists, at Tufts University, who've an extended history of promoting the idea of endocrine disruption. The statement entirely ignores state-of-the-art studies performed by researchers at the FDA and the National Toxicology Program examining true BPA exposure, metabolism, and excretionA in mice and monkeys in utero and postnatally, as well as a research reviewing major BPA exposure in humans. What these reports show is that: (Over the past few years, Trevor Butterworth has done an exceptional job of exposing the bad research behind the BPA juggernaut and has drawn focus on the work of Daniel Doerge of the FDA and the National Toxicology Program Aand Justin Teeguarden of the Pacific Northwest National Laboratory) These results from scrupulously made reports flatly contradicted the popular claims about experience of BPA and also call in to question a lot of the data regarding endocrine disruptors in general.A However, this work is nowhere mentioned in the IBCERCC record. This points up an over-all issue that also escaped the attention of the IBCERCC panel.A AThat is the issue of afalse positivesa in health studies.A In other words, false positives are originally reported results that gain attention a' often having a massive impact on the community and the press a' which aren't borne out when more demanding and effective studies are done to ensure the original effect. False positives are a tremendous problem.A The statistical methodologist John Ioannidis of Stanford has drawn attention to this problem with a 2005 report entitled aMost Research Findings Are False.a AAnd others have addressed the problem as well.ABut it is something to take note of the problem and quite still another to root it out, since difficult-to-obtain financing and professional growth hinge on researchersa publishing what seem to be fresh and essential findings.A Results that feed the general public concern about hazards in the environmental surroundings thus have a better potential for gaining attention from federal agencies whose mandate it to handle such hazards. In the end, the leadership of the NBCC, which was so instrumental in lobbying for development on prevention of breast cancer, was terribly disappointed by the end-product.A Laura Nikolaides, who's the organizationas director of research and quality care plans and was a of the committee, described NBCCas reaction to me.A After lobbying for 8 years, NBCC had wanted significantly more than aan empty statement that made a panel to publish another are accountable to sit on a shelf.a You'd think that someone on the committee or those managing its work would took issue with the uncritical and wrong-headed emphasis on substances in the environment.A But once created, committees tend to just take on a of their own, and their structure can determine the nature of results reached.A In the end, each of the participating teams a' scientists, government employees, and advocates a had its own times that overrode a reading of the research. In the course of discussing the issue of breast cancer prevention, many colleagues stated that, in one formulation, aThe desire to own some additional exposure to blame for breast cancer is very strong.aA AIt is understandable that advocates a several of them breast cancer survivors a' were influenced by the desire to spot a culprit in the surface world as a cause of breast cancer that might be prevented. What's harder to know is how, from their very different vantage points, scientists and bureaucrats uncritically accepted the reigning dogma regarding aendocrine disruptorsa based on shoddy studies that provided positive results, while supplying short shrift to state-of-the-art studies that offered a very different picture.AA In the end, advocates, scientists, and bureaucrats served as good enablers to advertise a view that pleased their preconceived ideas and personal agendas. Perhaps most shocking and disturbing is the fact that academic researchers and highly-placed officers at NIEHS and NCI could have recommended this uncritical and eventually distracting report.A While showing itself in a self-approving way to be about science, the survey is about something completely different.

To manage your diabetes, Weird Science recommends the munchies - Ars Technica

Marijuana may make you overeat, but it could be an effective diabetes treatment. Lighting up a bit of weed is often blamed for people going on uninhibited eating binges. So it's a bit of a surprise to find a study saying that regular marijuana use is associated with a slimmer waistline. Perhaps even more striking, however, is the affect it had on metabolism, where it drops resting blood glucose levels. These results are consistent with past indications that marijuana users have a lower incidence of diabetes. The one unusual thing here is that the new study found no indication of a dose response.

An early pregnancy test probably ended up killing lots of North American amphibians. We recently ran a story that suggested that international trade helped take a fungus that infects amphibians and turn it into a global killer. Now we have some idea of exactly what was being traded: raw materials for human pregnancy tests. The raw materials in question? Frogs. Xenopus laevis is commonly used in biology research because it's a prodigious producer of eggs that can then be used to study embryonic development. But, before we knew how to directly detect the proteins in human urine that signaled pregnancy, someone figured out a way to do so indirectly: they made the frogs ovulate.

So, we dragged in a bunch of frogs from Africa to use for pregnancy tests and, one way or another, they established themselves in the wilds of California. Now, a study of samples from frogs found decades ago in California and Africa show that these Xenopus are asymptomatic carriers of the fungus that's now killing other frog species around the globe. There's a very good chance that these hopping pregnancy tests managed to bring it to North America.

Living near a coal plant is bad, but it probably shouldn't be that bad. Here's a study that doesn't come from a happy place. And we mean that literally, as it comes from the Journal of Mood Disorders and its topic is suicide. Specifically, suicides in North Carolina (although that doesn't seem to be an especially unhappy place). After taking a variety of factors into account, the authors found that the rates in a given county went up if there were a coal-fired power plant in it. "The linear regression model suggests that for each additional coal plant in a given county, there would be an additional 1.96 suicide per 100,000 population," the authors conclude. No word on whether wind farms made people happier.

What could clear fire ants out of the US? Unfortunately, an ant that's even meaner. Fire ants are an invasive species in the warmer areas of the US, and we here at Weird Science are told by people who have experienced the invasion personally that their fearsome reputation is well deserved. So, normally, you'd expect said people to be happy to hear that the fire ants population seems to be going down. Unfortunately, it's going down because an even more deranged ant is driving it off—literally, a species called the crazy ant. On the plus side, these don't bite as viciously. On the downside, they manage to live in much higher densities, meaning they get everywhere once they get into someone's house.

Bonus Weird Science points both for the mere existence of a journal called Biological Invasions, where the paper will be published, and for the fact that entomologists were arguing over whether to call the species the "Raspberry crazy ant" or the "Tawny crazy ant." Until the paper is released, you can enjoy the press release.

Sports, where vagueness = profit. We typically think that carefully contemplating possible outcomes of an event is the best way to come to an accurate prediction of what's going to happen. But, when it comes from betting on sports, that may not be the case. Study participants were divided into two groups. One was asked to pick the winner of a sporting match while others were asked to pick the final score, which the researchers then converted into a prediction of the winning team. Oddly, there was a difference between the winner predicted by the two groups and the ones that didn't have to come up with a score ended up producing the more accurate prediction.

Normally, it's not clear whether these sorts of lab experiments translate to the real world. But in this case, the authors were able to turn to South Korea's largest sports-betting company, where they found exactly the same pattern holding.

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Race in the Park benefits breast cancer awareness - WTNH

The CT Race in the Park takes place in New Britain on Saturday May 11, and will benefit the Connecticut Breast Health Initiative.

For nine years, over 100,00 people have come together to support their loved ones by gathering for the races, walks and children's runs.

Most importantly,  people gather in solidarity and with one goal in mind—to help find a cure for breast cancer in our lifetime.

The 10th anniversary  of the event will include a Survivor Brunch, Sponsor's Tent, Food Vendors, Breast Cancer Researcher's Tent, Kid's Expo, entertainment, and more.

The Connecticut Breast Health Initiative's mission is to make a difference locally in the fight against breast cancer through education and research.

Via: Losing Weight May Ease Chronic Heartburn

Diabetes Is at an All-Time High in NYC - Complex.com (blog)

This news will definitely depress you. Over the last two decades, the adult diabetes rate in New York City has almost doubled. The Department of Health collected data which showed that some 650,000 adults had diabetes in 2011. Back in 1993, the number was 200,000 less. On top of that, they also suspect that there are 230,000 more adults who are unaware that they have diabetes.

The numbers from the past ten years are even more staggering. Over 10 percent of adults in New York City currently report having diabetes, whereas 4.2 percent of residents reported having it in 2003. It's gotten to the point that city officials are referring to it as an epidemic.

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Explore uncovers a potential factor of two proteins in diabetes - Medical Xpress - Medical Xpress.

(Medical Xpress)—Flinders University researchers are breaking new ground in a very decade-long journey to assess the function of two closely related proteins.

They now have data that reveals a task for these proteins within regulating cell metabolism. Disturbances in metabolism underlie a number of human diseases including type 2 diabetes, obesity along with cancer.

The team, led by Associate Professor Catherine Abbott through the School of Biological Sciences, has discovered that a pair of proteins called dipeptidyl peptidases (DP) 8 and 9 play a role in regulating at least 29 other proteins, the majority of which play important projects in metabolism and electricity production.

As a method to control blood glucose degrees, people with type 2 diabetes that do not respond to the drug metformin are made januvia or sitagliptin, a good drug to supress dipeptidyl peptidase-4 (DP4), which belongs to the same family of health proteins as DP 8 in addition to 9.

However, Associate Professor Abbott said that whenever tested at high dosages these drugs also inhibited DP 8 together with 9.

She said more research was now needed to look for the exact role of DP 8 in addition to 9 because "we don't know whether they have a good effect on metabolism and energy and managing blood sugar levels or a negative effect".

"Pharmaceutical companies claim their drugs are selective and don't bind to other proteins but also from high doses there's the possibility they could, " stated Associate Professor Abbott.

"What we should find out, and what this study suggests, is that if such drugs do block DP 8 and 9 it'd not necessarily be a nasty thing because DP 8 and 9 may be targets in the treatment method of diabetes, " this girl said.

"On the additional hand, blocking them might affect metabolism and energy with an adverse way, which tend to make the DP4 inhibitors hazardous. "

The research has just been published within the international Journal of Biological Chemistry as "Paper of the Week".

Only 50 to 100 forms are chosen as Paper of the Week from more when compared to 6000 manuscripts published inside journal each year, based on their significance and overall importance to your understanding of biological processes with a molecular and cellular level.

Associate Professor Abbott, who discovered DP 8 and 9 a lot more than 10 years ago, said the proteins and additionally DP4 may also may play a role in tumour growth, therefore a better understanding of their function may possibly also led to increased confidence inside safety of DP4 inhibitors or in a very new use for inhibitors being a cancer therapy.

Nanotechnology could help fight diabetes - MIT News.

The nanoparticles were manufactured to sense glucose levels in the childs body and respond by secreting the proper amount of insulin, and thus replacing the function from pancreatic islet cells, that happens to be destroyed in patients with Type 1 diabetes. Truly, this type of system could make it possible for blood-sugar levels remain nutritious and improve patients' total well being, according to the research workers.

"Insulin really works, but the problem is people don't always obtain the right amount of this. With this system from extended release, the level of drug secreted is proportional to the needs of the overall body, " says Daniel Anderson, a co-employee professor of chemical engineering and member of MIT's Koch Institute to get Integrative Cancer Research in addition to Institute for Medical Engineering and Science.

Anderson will be the senior author of a paper describing the revolutionary system in a recent issue with the journal ACS Nano. Lead author in the paper is Zhen Gu, some former postdoc in Anderson's lab. The research team moreover includes Robert Langer, a David H. Koch Institute Professor at MIT, and researchers within the Department of Anesthesiology at Boston Children's Hospital.

Currently, people with Type 1 diabetes typically prick their fingers repetitions a day to lure blood for testing their blood-sugar levels. When levels are high, these clients inject themselves with insulin, which in time breaks down the excess sugar.

Lately, many researchers have sought to cultivate insulin-delivery systems that could are an "artificial pancreas, " automatically detecting sugar levels and secreting insulin. One approach uses hydrogels to measure and interact with glucose levels, but some of those gels are slow so that you can respond or lack technical strength, allowing insulin to help you leak out.

The MIT team attempted to create a sturdy, biocompatible system that could respond more quickly to changes in glucose levels and would be simple administer.

Their system contains an injectable gel-like structure which includes a texture similar to toothpaste, claims Gu, who is now an assistant professor of biomedical archaeologist and molecular pharmaceutics for the University of North Carolina from Chapel Hill and Nc State University. The gel contains a blend of oppositely charged nanoparticles that attract 1, keeping the gel whole and preventing the particles from drifting away once inside body.

Using a modified polysaccharide called dextran, the researchers designed the gel to become sensitive to acidity. Each nanoparticle contains spheres of dextran full of an enzyme that changes glucose into gluconic acid. Glucose can diffuse freely in the gel, so when sugar levels are high, that enzyme produces large amounts of gluconic acid, making your neighborhood environment slightly more acidic.

That will acidic environment causes your dextran spheres to disintegrate, releasing insulin. Insulin subsequently performs its normal characteristic, converting the glucose inside bloodstream into glycogen, that's absorbed into the liver for storage.

In tests with mice that are fitted with Type 1 diabetes, the researchers found that her single injection of the gel maintained normal blood-sugar levels for typically 10 days. Because the particles are mostly made from polysaccharides, they are biocompatible and eventually degrade in the childs body.

The researchers are now wanting to modify the particles to enable them to respond to changes in blood sugar faster, at the acceleration of pancreas islet skin cells. "Islet cells are extremely smart. They can release insulin at enoromus speed once they sense high sugar levels, " Gu shows.

Before testing the dust in humans, the researchers plan to further develop the system's delivery properties and to work on optimizing the dosage that has to be needed for use inside humans.

"Clearly longer-term experiments are warranted, but on a closed-loop perspective, this can be a very clever approach to help you normalizing blood-glucose levels in people with diabetes, achieved by integrating the glucose sensing along with the insulin delivery, much to be a natural pancreatic beta cellular, " says Frank Doyle, a professor of chemical engineering within the University of California at Santa Barbara who was not system of the research team.

The research was funded through the Leona M. and Harry N. Helmsley Charitable Trust Foundation and also the Tayebati Family Foundation.

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Native woman organizes Lupus Curiosity Event in Clewiston : newszap. com.

CLEWISTON—May is normally Lupus Awareness Month your decide one local woman is fighting back about the disease to bring awareness for the community.

Lupus, an auto-immune disorder which unfortunately affects and damages different body parts, including the skin, joints and organs, affects about 1. 5 million Americans and at a minimum five million people world-wide, depending on the Lupus Foundation of The united states. Altovise Allen-Johnson, who was informed they have Lupus in July associated with 2000, is organizing your Lupus Awareness Event, being held within the John Boy Auditorium with Clewiston on May 19.

Allen-Johnson suffered from the effects of the disease for a long time before finally being determined. She explained how she was diagnosed with pneumonia five times a single year, before she asked her doctor to run a test for different diseases, among them Lupus.

"I had no freezing symptoms -- just fluid with my lungs, and fatigue together with fever -- but I actually didn't have any sneezing, any kind of cold symptoms, so As i couldn't associate that along with pneumonia. I figured an issue wasn't right, " stated Allen-Johnson.

Allen-Johnson said she had to ask her doctor to check her for any specified disease; when the results went back, she tested positive for Lupus.

"I felt allayed, " said Allen-Johnson, of hearing this news that she had lupus, "I felt relieved since I felt like now I'm able to treat the cause as opposed to the symptoms. Now I contain a name to this thing that's having with me... I can go from here now. "

Lupus is normal to the community with Hendry County. Dr. Udayashree Nune, Family Care Physician at the Forbes Family Care Centre in Clewiston, is currently treating five patients who have some form of lupus. Those patients wide variety in age from premature 20s to 86. Doctor. Nune explained that by means of lupus, there is "no discrimination. "

Another possibility is no discrimination as to help you who Lupus affects; nevertheless, 90 percent of all those diagnosed are women, in line with the Lupus Foundation of The country.

Dr. Nune also explained there exists few diagnosed cases from Lupus in Hendry Local, but most cases get undiagnosed. Non-specific fatigue is the commonest symptom, according to Dr. Nune; other symptoms comprise of vision problems, skin rashes, crippling or swollen joints, anemia, and hairloss, to name a few.

There are also different varieties of Lupus, which affect different areas of the body. Systemic lupus is the most widespread form, according to this Lupus Foundation of The states, and can be slight to severe. In significant cases, the kidneys is usually affected, which leads to kidney failure; in fact, in about 50 % of systemic lupus cases, a major organ, like the heart, lungs, kidneys or simply brain, is affected.

Medical professional. Nune went on to explain that Lupus can be with other auto-immune disorders, like fibromyalgia and rheumatoid arthritis. All of these difficulties, Dr. Nune explained, are "like a cluster, " with one adopting the other.

Allen-Johnson's Lupus Awareness Event was coordinated to create awareness about the disease to the community, as well when educate people about lupus, it's symptoms, and treatments.

"People don't know the conditions and people are tired and being misdiagnosed, " spelled out Allen-Johnson, "... I just want to say hey look, signs something is wrong, although it's not lupus, test me with this or that. " Allen-Johnson expressed how she wants visitors to get treated for the source, not just the warning signs.

Allen-Johnson went on to elucidate that, while there are charity events like Relay for Life, which raises money for cancers research, there are virtually no similar events for lupus.

"There's for no reason anything about lupus. Lupus requirements recognition. We go through the maximum amount of as any cancer persistent. There are a lot of us of this type with lupus, " talked about Allen-Johnson.

Strike out cancer at Relay For Life's 'Hula for Hope' - THV 11

MAUMELLE, Ark. (April 20, 2013) - The journey to end cancer starts with a single step. The American Cancer Society invites you to take that step with us by joining the global Relay For Life movement.

When you walk to end cancer at a Relay event, it's your opportunity to not only honor cancer survivors and remember loved ones lost, but also to raise awareness and funds to help find a cure for cancer.

This weekend Relay for Life Maumelle is gearing up for their walk next month with a fun event called 'Hula for Hope'.

This bowling tournament takes place today, April 20 from 3-5 p.m. at the Millenium Bowl in Maumelle. The winning team will talk away with a trophy, prizes and bragging rights.

There is still room for teams to compete or you can come out and cheer the participants on. There is a $100 entry fee for a team of 5 people, which includes 2 games of bowling and shoes.

And there's plenty of time to sign up for the Relay for Life event in Maumelle, which is set for May 17 at the Rolling Oaks Athletic Complex. Click here to sign up or donate.

Many forms of cancer increases bankruptcy risk, also for insured - NBCNews. com.

Cancer patients are much greater risk associated with bankruptcy than people free of cancer, according to a sizable new study. And whilst the new health care law promises insurance policy coverage to more than 30 million Americans who shortage it now, the higher cost of cancer attention can push many patients, especially younger women, straight into financial trouble, experts say.

Rates of women who are opting for preventive mastectomies, just like Angeline Jolie, have increased by a predicted 50 percent lately, experts say. But many doctors are puzzled considering that operation doesn't carry a 100 % guarantee, it's major surgery -- and women have other available choices, from a once-a-day product to careful monitoring.

"We need to seek out why this happening and see whenever a something we as a society can perform to reduce that associated risk, " says Dr. Scott Ramsey, director of the Hutchinson Institute for Many forms of cancer Outcomes Research in Seattle and lead author of the study published Wednesday with the journal Health Affairs.

Ramsey in addition to his colleagues matched 197, 840 adults from your western Washington cancer registry with an equal number of cancer-free parents by age, zip rule and sex. They then determined who had filed for bankruptcy, using court public records.

The researchers found that 4, 408 of those identified as having cancer between 1995 and additionally 2009 had filed meant for bankruptcy, compared to some, 291 of those free of cancer. Overall, cancer clients were 2. 5 times as likely as others to seek bankruptcy relief.

Non-white females were the foremost likely to file, while patients 65 or older were the smallest amount of likely -- possibly for the reason that were covered by Medicare and eligible to Social Security.

Bankruptcy rates associated with the younger groups were as many as 10 times that within the older patients. "People that definitely have fewer assets, less income and less generous insurance owing to entry level jobs or no insurance are definitely more vulnerable to severe fiscal distress, " Ramsey tells.

The highest rates of bankruptcy were those types of with thyroid cancer, that mostly affects younger females. The lowest were in men with prostate cancers, which typically strikes at an old age.

"They used a nifty way of getting this information, " says Dr. Jake Himmelstein, an internist and mentor of public health at the City University of Big apple. And though the researchers don't have home elevators the cancer patients' insurance coverage, "previous studies tell us that about three-quarters of people who say that illness was an essential factor in their bankruptcy had private medical insurance, at least when they first got sick, " Himmelstein says.

That rings true with regard to Janet Literski, 57, who had purchased medical insurance as an independent contractor working in sales. When she was identified as having non-Hodgkin's lymphoma in 08 Literski discovered her insurance covered only element of her surgical costs and none of her analysis tests. Then there were co-payments and deductibles. By way of the time she was informed they have pancreatic cancer two years later, she was a lot more than $150, 000 in healthcare debt.

In 2011, no longer able to work, Literski and additionally her disabled husband filed for bankruptcy. "It was a gut wrenching decision since you also feel like a very own failure, and that makes me angry because I had produced tried to do every thing right, " Literski shows. "I had health insurance policies, I was working. "

Literski is right now covered by Medicaid together with receives disability payments in addition to though she hasn't ended up told she's in remission, she says nancy "healthy enough. "

Ramsey says cancer centers want to do a better job associated with assessing each patient's fiscal status, offering credit counseling, and managing patient attention.

Steven Wieckowski, a financial counselor together with the national nonprofit GreenPath Unsecured debt Solutions, advises newly diagnosed tumor patients to assess that this diagnosis might impact their income; to review their medical insurance policy coverages; to determine whether they're agreed to a disability plan at the office; to prioritize their costs, putting housing, utilities, foods, car payments and child care on top of the list; and to reach out to credit card companies and the holders of student loans to demand deferral.

"When cancer strikes, a lot of folks feel so out of control, " Wieckowski says. These steps can put people back up in control of this percentage of their life. "

Ramsey is convinced the 2010 Patient Coverage and Affordable Care Action, which will extend health care insurance coverage to more when compared to 30 million Americans, might reduce bankruptcy rates.

However , Himmelstein, who examined Massachusetts bankruptcy rates 2 years after the state applied a health reform law like federal law, isn't positive.

"We found little and no impact, basically considering that insurance coverage people became was so skimpy not wearing running shoes offered inadequate financial cover, " he says.

Cancer Centers changes BOSS - Chicago Tribune

Gerard van Grinsven is appointed to take control as CEO of the Cancer Centers of America in July. (Henry Ford Medical Center photo / April 26, 2013) 4:16 p.m. CDT, April 26, 2013 Gerard van Grinsven, who'll simply take the lead part July 1, has been president and CEO of the Henry Ford West Bloomfield Hospital in suburban Detroit for seven years. Present CTCA President and CEO Stephen T. Bonner, who has kept these brands since 1999, will end up executive chairman of the Schaumburg-based business. It wasnat clear why the government transfer had been created or what would become of CTCAas present chairman, the organization was founded by Richard Stephenson, who in 1988. A speaker wasn't instantly offered to review Friday morning. sbomkamp@tribune.com

Twitter: @SamWillTravel It wasnat clear why the executive shift was being created, or what would become of CTCAas recent chairman, the organization was founded by Richard Stephenson, who in 1988. A speaker wasnat instantly available to comment.

Via: Solution to the riddle: food with more vitamin C is the guava

Lille Supreme Fit – Maxi Review.

This Lille Better Fit – Maxi Diaper Review is compiled by: Xanthia on ADISC. The looks of these are not something to be bragged about. They re plain white with the M pattern in it (assumably so you know which size they're just! ) and rectangular stripe down the center. As advertised the types is pretty spot …

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How H2o Will Boost Your Blog While Helping you Lose Weight.

The tragedy with blogging being profession is that whereas a cup of water every now and then will boost the output associated with a blogger, he or she never takes that cup associated with water. Seated down at their PC, they will bang separate at article after post without ever realising their requirement for this precious liquid. And who'd blame them, they probably sit all day in a room cooled by an air conditioning equipment. With no physical activity built in their routine, they never arrive at work up any being thirsty. The sedentary lifestyle made by their chosen craft may possibly also have caused the blogger to include on weight. If here is the story of your existence, help is not at all far away.

Water allows oxygen to help you flow into your brain helping you to think more clearly. All the toxins with the junk you eat and whatever else that doesn't belong in the human body, water flushes out. Water is nature's detox solution for our bodies. A detoxified body is usually what every blogger needs as this is a body in which air and circulation of blood happen without any burden. Drinking water is a much better alternative to coffee in regards to feeling alert. So whenever you feel an amount of mental lethargy creeping inside, most likely your system is dire need of the detoxifying powers of liquid. The solution? Drink copious degrees of water every day. This is what you should get your creative state of mind flowing, not gallons of one's drinks.

Water is highly recommended by the world's most trustworthy weight loss and healthy eating plan companies, like Bistro MD and Diet to travel. These companies specialize in producing and delivering your doorstep healthy, portion-controlled meals that you're supposed to take 6 times a day. However, they also encourage that you take plenty of water in between these meals. Many a blogger is wondering the direction to go with the tyres of flab around their abdomen acquired from years with sitting at their workstations churning out articles together with doing little else. Taking adequate amounts of water may have prevented the accumulation of fat for starters but specialists that water can help take it away. As you carry water frequently, your body can have the means to flush out the junk introduced into your physique by unhealthy eating.

On the above benefits, pouring water over a internal systems cools upon raging appetite hours of intense blogging should bring. Yes, it's true. Gulping down plenty of water will leave people with less room designed for burgers, pizzas and some other fattening foods. The trick is to achieve the water just before consumed to curb your food cravings. This habit will as well keep you from mistaking thirst for hunger and reaching for ones wrong kind of meals.

Author Bio-Latasri is a wellness enthusiast who likes to talk about her views on diets like DiettoGo and BistroMD. Moreover making available Bistro M . D . coupons she also blog about fitness, diet and fat loss on her website http: //www. weightlossdiets4women. com to get passionate bloggers.

Via: They warn of the serious health risks of diets to lose weight fast

Study finds circadian clock tempos altered in depression.

UC Irvine Health and wellbeing researchers have helped learn that genes controlling circadian clock rhythms are profoundly altered within the brains of people with severe depression. These time genes regulate 24-hour circadian rhythms affecting hormonal, body temps, sleep and behavioral patterns.

Depression is a serious disorder using a high risk for suicide affecting approximately one with 10 Americans, according for the Centers for Disease Restrain, and is ranked as fourth off diseases by the World Health Organization concerning lifetime disability. Study findings provide the pioneer evidence of altered circadian gene rhythms in brain tissue of people with depression and suggest a physical basis for you will find many symptoms that depressed affected individuals report.

The study – of which appears online this week in the Proceedings of the State Academy of Sciences – concerned researchers from UC Irvine Wellness, University of Michigan, UC Davis, Cornell Higher education, the Hudson Alpha Company for Biotechnology and Stanford University.

"Our findings involved the analysis of a large number of data involving 12, 000 gene transcripts from donated brain tissue from depressed and normal consumers. We were amazed that our data revealed that alarm clock gene rhythms varied around synchrony across six patches of normal human brain which these rhythms were significantly disrupted in depressed people. The findings provide signs for potential new instructional classes of compounds to rapidly treat depression that may reset abnormal clock family genes and normalize circadian tempos, " said Dr. William Bunney, the study's person author, and Distinguished Teacher of Psychiatry & Human Behavior at UC Irvine.

Circadian clock genes play an important role in regulating many body rhythms on the 24-hour cycle. Although animal data provide evidence for any circadian expression of body's genes in brain, little has been known as to whether you will find a similar rhythmicity in the mental faculties.

In the study, the researchers analyzed genome-wide gene expression patterns in brain samples from 55 people that have no history of psychiatric or neurological illness and compared it to the expression patterns around samples from 34 seriously depressed patients.

Lead novelist Jun Li, Ph. Defense., an assistant professor within the U-M Department of Human Genetics, describes how this tactic allowed the team to help accurately back-predict the hour for the day when each non-depressed man or woman died - literally plotting them from a 24-hour clock simply by noting which genes were active during the time they died. They viewed 12, 000 gene transcripts isolated from six instances of 55 brains from men and women that did not have major depression.

This provided a detailed idea how gene activity varied throughout the day in the brain parts studied. But when the team tried you need to do the same in that brains of 34 depressed individuals, the gene activity was off by a lot of time. The cells looked that it were an entirely different period.

"There really was some time of discovery, " says Li, who led the analysis for the massive amount of data generated by other team and is an investigation assistant professor in U-M's Unit of Computational Medicine for Bioinformatics. "It was when we realized that you will find many genes that show 24-hour cycles within the normal individuals were well-known circadian rhythm genes - of course, if we saw that the public with depression were not synchronized on the usual solar day in the case of this gene activity. It's that they were living in the different time zone compared to a one they died with. "

Huda Akil, Ph. Chemical., the co-director of a U-M Molecular & Behavioral Neuroscience Institute and co-director in the U-M site of a Pritzker Neuropsychiatric Disorders Homework Consortium, notes that the findings go above previous research on circadian rhythms, using animals or human skin cells, which were with less effort accessible than human head tissues.

"Hundreds of new genes that are very sensitive to circadian rhythms emerged out of this research - not just the most crucial clock genes which are studied in animals and cell cultures, but other genes as their activity rises and falls daily, " she says. "We were truly in a position to watch the daily rhythm play out in a symphony of biological activity, by studying where a clock had stopped at this time whilst death. And then, with depressed people, we could observe how this was disrupted. "

The investigators isolated various RNA samples from six elements of each brain and established the gene expression info around a 24-hour cycle influenced by time of death. Several hundred genes in both of six brain regions loaded rhythmic patterns of expression over the 24-hour cycle, including many genes required to the body's circadian machines.

- Sleep disorders can trigger mania or hypomania in people who had bipolar disorder. Interestingly, intentional sleep deprivation may well lead to short phrase mood improvement in those with depression.

- A standard symptom of depression is "early morning awakening" i. e. waking up several hours previous usual and not having the capacity to get back to sleep. A person who has morning awakening when they are depressed often also has less appetite than usual should they are depressed.

- A smaller group of people with depression have the contrary pattern of wanting to sleep considerably and feeling more keen than usual.

- Individuals who mood disorders tend of having more sleep difficulties in the vicinity of their mood disorder episodes compared to people who never been depressed.

- One style of depression is Seasonal Affective Syndrome (SAD), in which people have difficulties adjusting to the top of winter. (There is usually a spring/summer version of SAD but its less common than the cold weather version).

In the end, they had a near-complete familiarity with how gene activity varied in daytime in the cells within the six brain regions they will studied.

"There really was a point in time of discovery when we realized that most genes that we saw expressed with the normal individuals were well-known circadian rhythm genes – and once we saw that the people with depression were not synchronized to your usual solar day concerning this gene activity, " proclaimed Jun Li, an assistant professor inside Department of Human Genetics at the University of Michigan that led the analysis in the massive amount of data generated by all of those other team.

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Link: France confirms another case of affected person of coronavirus

Study finds circadian clock rhythms altered in depression

UC Irvine Health researchers have helped discover that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression. These clock genes regulate 24-hour circadian rhythms affecting hormonal, body temperature, sleep and behavioral patterns.

Depression is a serious disorder with a high risk for suicide affecting approximately one in 10 Americans, according to the Centers for Disease Control, and is ranked as fourth of all diseases by the World Health Organization in terms of lifetime disability. Study findings provide the first evidence of altered circadian gene rhythms in brain tissue of people with depression and suggest a physical basis for many of the symptoms that depressed patients report.

The study – which appears online this week in the Proceedings of the National Academy of Sciences – involved researchers from UC Irvine Health, University of Michigan, UC Davis, Cornell University, the Hudson Alpha Institute for Biotechnology and Stanford University.

"Our findings involved the analysis of a large amount of data involving 12,000 gene transcripts obtained from donated brain tissue from depressed and normal people. We were amazed that our data revealed that clock gene rhythms varied in synchrony across six regions of normal human brain and that these rhythms were significantly disrupted in depressed patients. The findings provide clues for potential new classes of compounds to rapidly treat depression that may reset abnormal clock genes and normalize circadian rhythms," said Dr. William Bunney, the study's senior author, and Distinguished Professor of Psychiatry & Human Behavior at UC Irvine.

Circadian clock genes play an important role in regulating many body rhythms over a 24-hour cycle. Although animal data provide evidence for the circadian expression of genes in brain, little has been known as to whether there is a similar rhythmicity in the human brain.

In the study, the researchers analyzed genome-wide gene expression patterns in brain samples from 55 individuals with no history of psychiatric or neurological illness and compared them to the expression patterns in samples from 34 severely depressed patients.

Lead author Jun Li, Ph.D., an assistant professor in the U-M Department of Human Genetics, describes how this approach allowed the team to accurately back-predict the hour of the day when each non-depressed individual died - literally plotting them out on a 24-hour clock by noting which genes were active at the time they died. They looked at 12,000 gene transcripts isolated from six regions of 55 brains from people who did not have depression.

This provided a detailed understanding of how gene activity varied throughout the day in the brain regions studied. But when the team tried to do the same in the brains of 34 depressed individuals, the gene activity was off by hours. The cells looked as if it were an entirely different time of day.

"There really was a moment of discovery," says Li, who led the analysis of the massive amount of data generated by the rest of the team and is a research assistant professor in U-M's Department of Computational Medicine at Bioinformatics. "It was when we realized that many of the genes that show 24-hour cycles in the normal individuals were well-known circadian rhythm genes - and when we saw that the people with depression were not synchronized to the usual solar day in terms of this gene activity. It's as if they were living in a different time zone than the one they died in."

Huda Akil, Ph.D., the co-director of the U-M Molecular & Behavioral Neuroscience Institute and co-director of the U-M site of the Pritzker Neuropsychiatric Disorders Research Consortium, notes that the findings go beyond previous research on circadian rhythms, using animals or human skin cells, which were more easily accessible than human brain tissues.

"Hundreds of new genes that are very sensitive to circadian rhythms emerged from this research - not just the primary clock genes that have been studied in animals or cell cultures, but other genes whose activity rises and falls throughout the day," she says. "We were truly able to watch the daily rhythm play out in a symphony of biological activity, by studying where the clock had stopped at the time of death. And then, in depressed people, we could see how this was disrupted."

The investigators isolated multiple RNA samples from six regions of each brain and arranged the gene expression data around a 24-hour cycle based on time of death. Several hundred genes in each of six brain regions displayed rhythmic patterns of expression over the 24-hour cycle, including many genes essential to the body's circadian machinery.

- Lack of sleep can trigger mania or hypomania in people with bipolar disorder. Interestingly, intentional sleep deprivation can also lead to short term mood improvement in people with depression.

- A common symptom of depression is "early morning awakening" i.e. waking up several hours earlier than usual and not being able to get back to sleep. A person who has early morning awakening when they are depressed often also has less appetite than usual when they are depressed.

- A smaller group of people with depression have the opposite pattern of wanting to sleep a lot and feeling more hungry than usual.

- People who have mood disorders tend to have more sleep difficulties outside of their mood disorder episodes compared to people who have never been depressed.

- One type of depression is Seasonal Affective Disorder (SAD), in which people have difficulty adjusting to the onset of winter. (There is also a spring/summer version of SAD but its far less common than the winter version).

In the end, they had a near-complete understanding of how gene activity varied throughout the day in the cells of the six brain regions they studied.

"There really was a moment of discovery when we realized that many of the genes that we saw expressed in the normal individuals were well-known circadian rhythm genes – and when we saw that the people with depression were not synchronized to the usual solar day in terms of this gene activity," said Jun Li, an assistant professor in the Department of Human Genetics at the University of Michigan who led the analysis of the massive amount of data generated by the rest of the team.

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New program successful in trimming service and substance use among frequent healthcare users.

An opportunity co-led by St. Michael's Hospital might be the next widely used model to treat patients who are frequent users of the health care system and have severe addictions, often complicated by homelessness and mental health problems.

The Toronto Community Addiction Team (TCAT) was created to improve health and social outcomes for people with addictions who are repeated users of health services by providing one-on-one intensive case management from your harm reduction approach. The team works together clients to provide services such as individual therapy, finding your doctor, securing housing, managing budgets and care plans that are based on clients' strengths and opportunities.

"Developing interventions to employ these frequent users within community-based care and overcome pressures from costly hospital-based services - which are not designed to satisfy their needs – is often a system priority, " said Dr. Vicky Stergiopoulos, psychiatrist-in-chief from St. Michael's Hospital and evaluation lead to your program. "The TCAT is an effective example of a client-centred approach that works to perform exactly this. It shows promise inside reducing re-admission rates which can ultimately save money for ones health care system. "

The program provides city-wide mobile intensive case management for those who have frequent re-admissions to some withdrawal management system - 10 or higher in a year : and and/or hospital urgent situation departments - 20 or maybe more in a year.

"Many of patients cycle between imprisonment, the shelter system, withdrawl organization and hospitals, " Medical professional. Stergiopoulos said. "They can't discover services, and the services aren't helpful because many of them only accept patients in which are at a different place in the recovery process. The TCAT works with strength-based principles and supports people from a harm reduction orientation. The program is uniquely aimed at empowering the client simply by promoting respect and dignity so they can make their own solutions. "

Dr. Stergiopoulos led the course evaluation, published online inside the journal Substance Use and Misuse this month.

Based on interviews with clients and an assessment records from the Disengagement Management System, the results found a statistically significant decreases operating use, alcohol and drug use. Clients also described increased entry to primary and psychiatric attention and increased collaboration with various stakeholders within the wider system of attention.

Dr. Stergiopoulos said the goal is to divert care for these patients on a place like the emergency department for the community because it will improve outcomes for both the patients and the method.

"This model worked well inside the city of Toronto, and might be considered in other large urban centres this face similar challenges by means of frequent service users who have alcohol and drug related problems, often complicated by homelessness and lack of support and resources, " the girl said.

St. Michael's Hospital provides compassionate care to everyone who enter its entry doors. The hospital also gives you outstanding medical education to health and wellness care professionals in around 23 academic disciplines. Vital care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer attention, and care of the homeless are among the Hospital's recognized areas from expertise. Through the Keenan Research Centre and the Li Ka Shing Global Healthcare Education Centre, which aid up the Li Ka Shing Know-how Institute, research and education and learning at St. Michael's Hospital are recognized and make an impact globally. Founded in 1892, the hospital is fully affiliated with the University of Toronto.

Kate Taylor Communications Mechanic St. Michael's Hospital Cellular: 416-864-6060 x. 6537 Influenced Care. Inspiring Science

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Mariners 3B coach reveals cancer - ESPN

SEATTLE -- Seattle Mariners third-base coach Jeff Datz said Saturday he has been diagnosed with cancer and might be away from the team for part of the season.

Datz told Mariners' players during a team meeting before Saturday's game against the Los Angeles Angels and later released a written statement. Datz said he's still in the process of making decisions on treatment and he might have to miss some games.

"The good news is that it was caught very early, and I have great support from my wife, my family, Eric (Wedge), the coaches and staff, all the players and the Mariners organization," Datz wrote.

Datz said he released the statement because he doesn't want his absence to be a distraction. He declined further comment until decisions on timing and treatment have been made.

"He's going to beat this. We've all experienced cancer in some way, shape or form and it's something he's been dealing with, we've all been dealing with for a couple of weeks and we felt like it was the right time to announce it to the team because he is going to miss some time away from the team at some point in time," Wedge said. "He's touched a lot of people throughout the country over the years, I'm sure they're all going to reach out and give their total support.

The 53-year-old Datz is in his third season with the Mariners. He previously worked on coaching staffs with Baltimore and with Wedge during his tenure as manager in Cleveland. Wedge first got to know Datz in 1998. Wedge was getting his start as a minor league manager and Datz was working a level above in the Indians' minor league system. He was on Wedge's staff for eight seasons in Cleveland.

"I told him, 'You're going to beat it.' It's as simple as that," Wedge said. "Everybody is going to do what they need to do to help him and then he'll be back in good shape."

Texas Teacher's Cancer Fight Inspires Students - ABC News

But the suburban Dallas middle school science teacher fought back against pancreatic cancer for close to two years and reached a milestone — 25 years on the job.

But even the iron-willed Templer has limits. She's had to stop her school year early—she's in hospital now focusing squarely on her cancer fight.

Lupus patient seminar will be held May 18 at Alumni Center - WJBF-TV

The Lupus Foundation of America estimates that 1.5 million Americans have a form of lupus. However, due to improved diagnosis and disease management, most people with the disease will go on to live a normal life span.

Patients and families affected by lupus can learn more at the annual Augusta Living with Lupus Symposium from 1 to 5 p.m. Saturday, May 18 at the Georgia Regents University Alumni Center. The event, presented by GRU and the Lupus Foundation of America's Georgia Chapter, will include expert advice from a cardiologist, nutritionist and an athletic trainer, as well as testimonials from people who are living with lupus.

Lupus is a chronic, autoimmune disease in which the body attacks itself, damaging the skin, joints, kidneys and blood. Symptoms vary from headaches, fatigue and rash to hair loss, mouth and nose ulcers, and anemia.

"There are many misconceptions out there. But a lupus diagnosis is not hopeless," said Dr. Alyce Oliver, a rheumatologist at Georgia Regents Medical Center and an Associate Professor in GRU's Medical College of Georgia. "There are effective drugs and treatments that can improve a patient's quality of life."

For more information about the Lupus Symposium or to register for the event, call 770-333-5930 or visit lupusga.org.

To schedule a consultation at the Georgia Regents Lupus Multi-Specialty Clinic, have your primary care physician call 706-721-1450 for further information.

SHAREHOLDER AWARE: Brower Piven Encourages Investors Who definitely have Losses... - GlobeNewswire (press release).

STEVENSON, M . d .., May 13, 2013 (GLOBE NEWSWIRE) -- Brower Piven, A Professional Corporation announces that the class action lawsuit has been commenced in the usa District Court for a Southern District of New York on behalf of purchasers of Ventrus Biosciences, Inc. ("Ventrus" or the "Company") (Nasdaq: VTUS) common stock in the period between December seventeen, 2010 and June 31, 2012, inclusive (the "Class Period").

Should you have suffered a net loss from investment in Ventrus Biosciences, Inc. common stock purchased on or simply after December 17, 2010, and held through June twenty-five, 2012, you may obtain additional information about this lawsuit and your ability to become lead plaintiff by getting in contact with Brower Piven at online world. browerpiven. com, by e-mail at hoffman@browerpiven. com, as a result of calling 410/415-6616, or with Brower Piven, A Professional Corporation, 1925 Old Pit Road, Stevenson, Maryland 21153. Attorneys at Brower Piven have got combined experience litigating securities and class action cases of over 60 years.

No class has yet been certified in the above action. Members for the Class will be represented from the lead plaintiff and counsel chosen from the lead plaintiff. If you need to choose counsel to represent you and the Class, you must connect with be appointed lead plaintiff zero later than July 8, 2013 and grow selected by the Court. The lead plaintiff might direct the litigation and play important decisions including whether to simply accept a settlement and what amount of of a settlement in order to for the Class inside the action. The lead plaintiff can be selected from among applicants claiming the largest loss from investment inside Company during the Category Period.

The complaint accuses your defendants of violations in the Securities Exchange Act with 1934 by virtue for the defendants falsely representing over the Class Period that their lead product iferanserin (VEN 309) ("VEN 309"), for the topical treatment of symptomatic internal hemorrhoids, was an unusual product that had simply no competing products approved by way of the U. S. Food and Drug Administration ("FDA"), that VEN 309 would be the first and only product or service specifically approved for use being a prescription treatment for hemorrhoids, that the prior stage II and IIB reviews of VEN 309 constantly demonstrated reduction of hemorrhoidal conditions, that the Company can leverage VEN 309 to your market of over 12. 5 thousand thousand potential patients, and of the fact that Phase III clinical litigation for VEN 309 was "low risk" relative to most therapeutic drug advancement programs. According to this complaint, following the Firm's June 25, 2012 disclosure that VEN 309 were unable its Phase III trial prior to the FDA and that this company would abandon further improvement of VEN 309, including deeper attempt to obtain FDA acceptance, the value of Ventrus stock shares declined significantly.

If you choosed retain counsel, you may retain Brower Piven without the need of financial obligation or cost to you, or you may retain other counsel with the choice. You need take no action at this time to be a person in the class.

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Agent Orange exposure linked to deadliest form of prostate cancer in Vietnam ... - CBS News

Exposure to Agent Orange may be behind many cases of an aggressive form of prostate cancer being seen in Vietnam War veterans, according to new research.

Millions of gallons of herbicide Agent Orange was sprayed by the U.S. military on trees and other vegetation during the Vietnam War era, and has been linked to various health effects since. The combination of herb-killers was named for the orange identifying stripe used on the 55-gallon drums that stored the chemicals.

The authors of the new study say the herbicide was often contaminated with dioxin, a dangerous toxin that may cause cancer.

Veterans who served anywhere in Vietnam between January 9, 1962 and May 7, 1975 may have been exposed to the chemical, according to the U.S. Department of Veterans Affairs.

The Department has linked exposure to the chemical to various health conditions including AL amyloidosis, chronic B-cell leukemias, Type 2 diabetes, Hodgkin's disease, Non-Hodgkin ischemic heart disease, multiple myeloma, Parkinson's disease and prostate cancer, among other conditions.

The VA says veterans with prostate cancer who were exposed to Agent Orange or other herbicides during military service may be eligible for disability compensation and health care.

The new study, which looked at prostate cancer rates among veterans, adds to the evidence of a link between Agent Orange exposure and the disease. The researchers found higher rates of the deadliest, most-aggressive forms of prostate cancer among veterans.

"This is an important distinction as the majority of prostate cancer cases are non-lethal and thus do not necessarily require detection or therapy," study author Dr. Mark Garzotto, a physician at the Portland Veterans Administration Medical Center and Oregon Health & Science University, said in a press release. "Having a means of specifically detecting life-threatening cancer would improve the effectiveness of screening and treatment of prostate cancer."

Garzotto and colleagues studied more than 2,700 U.S. veterans after they were referred to a clinic for a prostate biopsy. Prostate cancer was diagnosed in nearly 900 of the patients -- about 33 percent of the study participants -- but 459 of the patients had a more aggressive, high-grade disease. The researchers determined exposure to Agent Orange was linked to a 52 percent increase in prostate cancer risk, and a 75 percent increase in the deadliest forms of the disease. Exposure to the chemical was not linked to an increased risk for low-grade prostate cancer.

Researchers behind the study, which was published May 13 in the American Cancer Society's journal Cancer, say their findings suggest that Agent Orange exposure history should be incorporated into veterans' decisions on whether to get screened for prostate cancer.

Garzotto said the study should "raise awareness about potential harms of chemical contaminants in biologic agents used in warfare and the risks associated with waste handling and other chemical processes that generate dioxin or dioxin-related compounds."

Dr. David B. Samadi, a urologist and chief of robotics and minimal invasive surgery at the Icahn School of Medicine at Mount Sinai in New York City, who was not involved with the study, pointed out to Everyday Health that the level of exposure a veteran got determined his or her risk.

"The closer you are to the source, the amount, and the duration of exposure have a huge correlation with the chance of developing prostate cancer," he said. ""It can change the DNA and send a cell into a different cycle, making it a cancer cell."

The study had limitations, according to Dr. Arnold Schecter of the University of Texas School of Public Health's Environmental and Occupational Health Sciences Program in Dallas.

He told Reuters there's a "big problem" with just asking veterans if they were exposed to Agent Orange or served in an area where it was sprayed.

"Of those most heavily exposed in the military as best we know, only a relatively small percentage of them had elevated dioxin from Agent Orange in their blood when tested," Schecter, who was not involved in the study, told Reuters.

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