The number of women being identified as having metastatic breast cancer has been slowly but steadily growing over the past 3 decades, a national study found. The occurrence of advanced level breast disease among women ages 25 to 39 crept upward by 2.1 % each year between 1976 and 2009, based on Dr. Rebecca Johnson of Seattle Children's Hospital and the University of Washington in Seattle, and peers. The upward trend wasn't seen among older women in the analysis of the Surveillance, Epidemiology, and Results (SEER) database, revealed in the Feb. 27 issue of the Journal of the American Medical Association. Read this story on www.medpagetoday.com. The results are worrying for an "age group that already has the least medical health insurance, no recommended routine screening practice, the worst treatment, and the many potential years of life," the scientists described. Why more women will be presenting with tumors which have already spread to bone, mind, lungs, or other remote sites isn't clear, they mentioned. Growing obesity costs, changes in liquor and tobacco use, and genetics are possible causes, in accordance with Dr. Thomas Julian, director of surgical oncology at Allegheny General Hospital in Pittsburgh. Whatever the cause, some thing must be achieved to get these girls at an earlier in the day phase of cancer, he told MedPage Today within an interview. "That is a problem unless you know there are genetics in the family or a powerful family history," he explained since we do not often display before age 40. The analysis of three SEER registries comprising 1973-2009, 1992-2009, and 2000-2009 showed a growth from 1.53 to 2.90 per 100,000 in incidence of breast cancer with remote metastases beyond the lymph nodes or adjacent areas among girls, ages 25 to 39, over that point period. That age bracket did not appear to have a turning point for the increase in metastatic cancer incidence, but the development appeared to be increasing. The steepest uptick occurred in the most up-to-date period from 2000-2009, where occurrence increased 3.6 percent each year. As metastatic display increased as a percentage of all invasive breast cancer in the 25 to 39 age group, from 4.4 percent in the 1970s to 7.2 percent after the change of the century, another point of data. Moreover, "there is no evidence for period migration from local, local, or in situ groups, none of which had a decrease in incidence anytime since 1976," the researchers noted. Even though the increase appeared to have already been more in the estrogen receptor-positive subtypes than estrogen receptor-negative disease, the developments were seen among all races and nationalities and urban and non-urban areas alike. Smaller increases were shown progressively by women ages 40 and older in metastatic presentation by age group, without any major trends in any group 55 years or older except for an increase in localized disease associated with the start of screening mammography programs throughout the 1980s.
Via: Manuel Pellegrini: I do not think that it was a surprise that we spend
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